Scientist II - Analytical

Apollo Professional Solutions; San Diego (CA); On-site; USD 83,000 - 117,000; Full time

Job summary

Apollopros is seeking a Scientist II – Analytical (Contract) to advance gene therapy research in San Diego, onsite only. You will develop and implement analytical methods for lipid nanoparticle formulations and support cross‑functional teams in a fast‑paced environment.

The role emphasizes HPLC/BLI technics, data analysis, rigorous documentation, and collaboration with formulation and process development groups.

Qualifications

• Bachelor's or Master's degree in Pharmaceutical Sciences, Bioengineering, Chemical Engineering, Chemistry or related discipline; minimum 5 years of industry experience.
• Hands‑on experience developing analytical methods using gradient‑elution HPLC (RP, IP‑RP, AEX); strong method development and troubleshooting skills.
• Excellent written and verbal communication; ability to organize data and documentation meticulously.
• Experience collaborating with cross‑functional teams in a fast‑paced research environment.

Responsibilities

• Perform analytical characterization of lipid nanoparticles (LNPs) and components.
• Conduct testing and data analysis using HPLC and BLI techniques.
• Develop, optimize, and qualify analytical methods for nanoparticle characterization.
• Investigate relationships between nanoparticle properties and biological safety/efficacy; maintain thorough records.
• Collaborate with formulation, process development and research scientists; support lab operations.

Skills

Attention to detail

Data analysis

Communication skills

Team collaboration

Education

Bachelor's or Master’s degree in Pharmaceutical Sciences / Bioengineering / Chemical Engineering / Chemistry

Tools

HPLC

BLI

SPR

LC‑MS

GraphPad Prism

JMP

Excel

Job description

Scientist II – Analytical (Contract)

Location: San Diego, CA (Onsite Only)

Contract Duration: 6 Months, with Potential Extension Relocation Assistance: Not Available

Advance the Future of Gene Therapy and Genome Editing

We are seeking a talented Scientist II – Analytical to join an innovative Gene Medicines team focused on developing next-generation nucleic acid delivery technologies for in vivo genome editing and gene therapy applications. This is an exciting opportunity to work with cutting‑edge lipid nanoparticle (LNP) therapeutics and contribute to the analytical characterization of novel pharmaceutical formulations. The successful candidate will collaborate with multidisciplinary scientific teams, develop analytical methods, and help generate critical insights into the performance, safety, and effectiveness of advanced nanoparticle‑based medicines.

Key Responsibilities

• Perform analytical characterization of lipid nanoparticles (LNPs) encapsulating nucleic acids, as well as individual LNP components.
• Conduct testing and data analysis using High-Performance Liquid Chromatography (HPLC) and Biolayer Interferometry (BLI) techniques.
• Develop, optimize, and qualify analytical methods used for nanoparticle characterization.
• Investigate relationships between physicochemical properties of experimental nanoparticle formulations and their biological efficacy and safety profiles.
• Maintain accurate, comprehensive, and well‑organized analytical records and scientific documentation.
• Collaborate closely with cross‑functional teams including formulation, process development, and research scientists.
• Support laboratory operations through activities such as: Inventory and supply management Instrument calibration and maintenance Laboratory scheduling and coordination
• Effectively communicate experimental findings, technical observations, and recommendations to project teams.

Required Qualifications

• Education & Experience Bachelor's or Master's degree in: Pharmaceutical Sciences Bioengineering Chemical Engineering Chemistry Related scientific discipline Minimum of 5 years of relevant industry or research experience. Equivalent combinations of education and experience may be considered.
• Technical Skills Hands‑on experience developing analytical methods using gradient‑elution HPLC techniques, including: Reverse Phase (RP) Ion‑Pair Reverse Phase (IPRP) Anion Exchange Chromatography (AEX) Strong understanding of analytical method development, optimization, and troubleshooting. Proficiency with Microsoft Excel for data analysis and reporting.
• Professional Skills Exceptional attention to detail with a demonstrated ability to generate accurate, reproducible results. Strong organizational and documentation practices. Excellent verbal and written communication skills. Ability to manage multiple projects simultaneously while maintaining high‑quality standards. Collaborative mindset with a proven ability to work effectively in a team‑oriented research environment.

Preferred Qualifications

• Hands‑on experience with Biolayer Interferometry (BLI) or Surface Plasmon Resonance (SPR).
• Experience utilizing Liquid Chromatography‑Mass Spectrometry (LC‑MS) for analytical characterization.
• Familiarity with advanced data analysis and statistical software such as: GraphPad Prism JMP.
• Experience supporting analytical development within biotechnology, pharmaceutical, gene therapy, or drug delivery programs.

Why Join This Opportunity?

This position offers the chance to contribute to groundbreaking advancements in gene therapy, genome editing, and nanoparticle drug delivery technologies. You'll work alongside highly skilled scientists in a collaborative research environment while gaining exposure to innovative therapeutic platforms that have the potential to transform patient care.

Keywords: Scientist II Analytical, Analytical Scientist, Gene Therapy, Genome Editing, Lipid Nanoparticles, LNP Characterization, HPLC Scientist, Biolayer Interferometry, BLI, Surface Plasmon Resonance, SPR, LC‑MS, Pharmaceutical Sciences, Bioengineering, Analytical Method Development, Drug Development, Biotechnology Careers, San Diego Scientist Jobs, Contract Scientist, Gene Medicines.