Analytical Scientist II: Lipid Nanoparticles & Gene Therapy

IT Engagements, Inc.; San Diego (CA); On-site; USD 69,000 - 96,000; Full time

Job summary

IT Engagements seeks a Scientist II - Analytical to join the Medicines team in San Diego, CA. The role focuses on non-viral nucleic acid delivery tools for in vivo genome editing and gene therapy, analyzing lipid nanoparticle-based pharmaceuticals.

You will develop methods (HPLC/BLI) for LNPs, maintain detailed data records, and collaborate with cross-functional teams to advance projects. A 5+ year background in pharmaceutical sciences is required.

Qualifications

• Master's or Bachelor's degree in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or related scientific discipline.
• Experience developing methods in gradient-elution HPLC modalities such as RP, IPRP, or AEX.
• Experience with BLI or SPR is highly desirable.
• Experience with LCMS is desirable.
• Excellent attention to detail and ability to produce consistent results and communicate them to the team.
• Ability to be a team player, multitask and work on multiple projects in a collaborative environment.
• Proficiency in MS Excel; experience with Prism and JMP desirable.
• Excellent oral and written communication skills.

Responsibilities

• Work at the direction of Analytical scientists to analyze lipid nanoparticles (LNPs) encapsulating nucleic acids and LNP components using HPLC and BLI.
• Develop methods to characterize LNPs and LNP components.
• Establish relationships between physiochemical characteristics of experimental nanoparticle formulations and their efficacy and safety.
• Maintain detailed records of analytical data.
• Interface directly with other functional teams.
• Share responsibility for basic lab management activities (supply ordering, instrument calibration, maintaining schedules).

Skills

HPLC methods

BLI or SPR

LCMS (desirable)

MS Excel

Communication skills

Education

Bachelor's degree

Master's degree

Tools

Prism

JMP

MS Excel

Job description

IT Engagements seeks a Scientist II - Analytical to join the Medicines team in San Diego, CA. The role focuses on non-viral nucleic acid delivery tools for in vivo genome editing and gene therapy, analyzing lipid nanoparticle-based pharmaceuticals.

You will develop methods (HPLC/BLI) for LNPs, maintain detailed data records, and collaborate with cross-functional teams to advance projects. A 5+ year background in pharmaceutical sciences is required.