Research Scientist, Precision Genome Editing & Therapeutics

Broad Institute; Cambridge (MA); Presencial; USD 150.000 - 190.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Medical, dental, vision

401(k) retirement plan

Paid holidays and time off

Parental and family leave

Descripción de la vacante

The Broad Institute in Cambridge, MA, seeks a scientist to advance nonclinical genome-editing programs (base and prime editing) and drive data generation toward IND-enabling readiness. You will design and analyze editing experiments, lead off-target profiling, and run high-throughput screens in collaboration with disease biologists and external partners to optimize editor design and study outcomes.

Strong publication history and excellent communication skills are essential to translate complex

Formación

• PhD in molecular biology, genetics, genome engineering, biomedical engineering, or a related field; or a Master’s with 5+ years of experience; or Bachelor’s with 7+ years of experience.
• Proven track record of deep expertise in base editing and/or prime editing.
• Experience with unbiased genome-wide specificity profiling methods (GUIDE-seq, Digenome-seq, CIRCLE-seq, ONE-seq, CHANGE-seq).
• Experience designing and executing high-throughput lentiviral screens.
• Proficiency in HTS library preparation and amplicon sequencing; able to analyze sequencing data.
• Familiarity with preclinical/IND-enabling study design; interest in neurologic/metabolic diseases a plus.
• Excellent written and verbal communication; able to translate complex genome editing science for cross-functional audiences.

Responsabilidades

• Design, execute, and analyze experiments evaluating precision genome editing technologies across CTG programs.
• Lead off-target and specificity profiling workstreams using genome-wide methods to inform go/no-go decisions.
• Design and execute high-throughput screens to identify editing strategies and guide/pegRNA designs.
• Develop and analyze high-throughput sequencing-based assays and interpret data for nonclinical packages.
• Contribute to preclinical program strategy, including editor design and study design.
• Evaluate emerging editing platforms and provide technical assessments for partnerships.
• Prepare data summaries, figures, and reports for internal reviews, external reports, and regulatory submissions.
• Mentor junior scientists and collaborate with internal and external partners.

Conocimientos

Base editing

Prime editing

Genome editing

HTS data analysis

Scientific communication

Educación

PhD in molecular biology or related field

Herramientas

GUIDE-seq

Digenome-seq

CIRCLE-seq

ONE-seq

CHANGE-seq

PEG-seq

Descripción del empleo

The Broad Institute in Cambridge, MA, seeks a scientist to advance nonclinical genome-editing programs (base and prime editing) and drive data generation toward IND-enabling readiness. You will design and analyze editing experiments, lead off-target profiling, and run high-throughput screens in collaboration with disease biologists and external partners to optimize editor design and study outcomes.

Strong publication history and excellent communication skills are essential to translate complex