Computational Biology Scientist I — Genomics & Gene Editing

Crispr Therapeutics Inc in; Boston (MA); Hybrid; USD 120,000 - 130,000; Full time

Benefits offered by this job

Equity and benefits

Remote-friendly with on-site collab

Job summary

CRISPR Therapeutics, Inc. in Boston is seeking a Computational Biology Scientist to advance next‑gen gene editing therapies. You will lead computational biology and genomics activities, develop pipelines, analyze off‑target effects, and support IND submissions.

You will maintain infrastructure and internal web tools, enabling reproducible analyses for cross‑functional teams. The role requires strong Python, Linux, and cloud experience, a PhD in a related field, and a passion for translating data

Qualifications

• Ph.D. in computational biology, bioinformatics, genomics, computer science, or related field with 0-2+ years of industry experience; an M.S. with an exceptional track record and eight+ years considered.
• Proficiency in Python is essential.
• Experience with Linux and large-scale genomic datasets; cloud computing (AWS).
• Ability to work independently in a matrix environment and balance priorities.
• Commitment to scientific rigor and meticulous attention to detail.

Responsibilities

• Lead computational biology and genomics activities in a cross-functional drug development setting.
• Develop and implement novel computational pipelines and methods with biologists.
• Characterize off-target gene editing to ensure safety of CRISPR products.
• Generate hypotheses from genome-scale data using analytical methods.
• Produce rigorous research reports for IND submissions and regulatory filings.
• Maintain computational infrastructure and cloud environments for reproducible analyses.
• Develop internal web applications to share methods and results with stakeholders.

Skills

Python

Genomics analysis

Statistical analysis

Education

Ph.D. in computational biology or related field

M.S. with exceptional track record and 8+ years experience

Tools

BWA

SAMtools

BEDTools

GATK

IGV

Nextflow

AWS

Linux

Illumina

PacBio

Oxford Nanopore

10x Genomics

Django

React

MySQL

Job description

CRISPR Therapeutics, Inc. in Boston is seeking a Computational Biology Scientist to advance next‑gen gene editing therapies. You will lead computational biology and genomics activities, develop pipelines, analyze off‑target effects, and support IND submissions.

You will maintain infrastructure and internal web tools, enabling reproducible analyses for cross‑functional teams. The role requires strong Python, Linux, and cloud experience, a PhD in a related field, and a passion for translating data