Scientist - Genome Engineer in New York

Energy Jobline ZR; New York (NY); On-site; USD 120,000 - 190,000; Full time

Job summary

Energy Jobline ZR in New York, NY is seeking a Scientist - Genome Engineer to design, build, and validate genome editing approaches in human cellular disease models. This foundational hire will shape the platform, lab, and scientific culture, collaborating directly with the founding team. The role requires leadership, independent work, and the ability to drive IND-enabling studies and future patent filings.

Qualifications

• PhD in genetics, molecular biology, bioengineering, genome engineering or closely related field.
• Hands-on expertise with precision genome editing tools: CRISPR-Cas nucleases, base editors, prime editors, and the design and screening workflows around them.
• Demonstrated experience with multiple delivery systems.
• Experience editing primary cells or therapeutically relevant cell types with quantitative readouts.

Responsibilities

• Design and execute on multiple precision editing strategies.
• Build and screen libraries; optimize editing efficiency, purity and product outcome in primary cells and relevant disease models.
• Develop and compare delivery approaches across viral and non-viral delivery systems.
• Run specificity and safety assessment: off-target nomination and validation, translocation and large-deletion analysis.
• Own experimental design, data analysis and documentation to IND-enabling and patent-support.
• Manage additional team members, equipment, protocols, vendor relationships.

Skills

Experimental design

Data analysis

Independent work

Communication skills

Team leadership

Education

PhD in genetics

Tools

CRISPR-Cas

Base editors

Prime editors

Delivery systems

Job description

Job Description

We are early-stage startup focused on the genetic underpinning of common diseases. We are hiring a Scientist - Genome Engineer to design, build and validate existing and novel editing approaches in human cellular models of disease.

You will own all editing work from design, testing, readout and iterative cycles of optimizations. As foundational scientific hire, you will shape our platform, our lab and our scientific culture, working directly with the founding team.

What you will do

• Design and execute on multiple precision editing strategies
• Build and screen libraries; optimize editing efficiency, purity and product outcome in primary cells and relevant disease models.
• Develop and compare delivery approaches across viral and non-viral (LNP, RNP electroporation, nanoparticle) delivery systems.
• Run specificity and safety assessment: off-target nomination and validation, translocation and large-deletion analysis, and the assays our regulatory path will require.
• Own experimental design, data analysis and documentation to a standard that supports IND-enabling work and patent filings.
• Manage additional team members, equipment, protocols, vendor relationships.

Required qualifications

• PhD in genetics, molecular biology, bioengineering, genome engineering or a closely related field.
• Hands-on expertise with precision genome editing tools: CRISPR-Cas nucleases, base editors, prime editors, and the design and screening workflows around them.
• Demonstrated experience with multiple delivery systems.
• Experience editing primary cells or other therapeutically relevant cell types, with quantitative readouts (NGS-based editing analysis, PCR, flow cytometry).
• Strong experimental design and data analysis skills; comfort with sequencing data and standard bioinformatic tools for editing outcome analysis.
• Ability to work independently in a small team, build reports and presentations.
• Excellent communication skills.
• Authorized to work in the United States and on-site.

qualifications

• Published, peer-reviewed work on gene editing technologies.
• Highly skilled at multitasking and AI tool integration.

We are an equal opportunity employer.