Proteomics Scientist - Automation & Mass Spec in TPD Core

Dana-Farber Cancer Institute; Boston, Northern (MA, KY); Hybrid; USD 80,000 - 96,000; Full time

Job summary

Dana-Farber Cancer Institute in Boston is seeking a Scientist I / Research Scientist to join the TPD Core. The role uses mass spectrometry to study proteome-wide responses to perturbations and contribute to projects on targeted protein degradation with emphasis on automation and workflow development.

You will lead experiments (TMT, DIA, DDA), maintain instruments, and collaborate across teams to advance cancer biology research while upholding data integrity and safety standards.

Qualifications

• Ph.D. in biochemistry, analytical chemistry, bioengineering or related field.
• Strong expertise in mass spectrometry-based proteomics and data analysis.
• Hands-on experience operating Thermo and/or Bruker mass spectrometers.
• Experience with laboratory automation, robotics, or pipeline development.
• Proficiency with quantitative proteomics and enrichment techniques.
• Familiarity with data analysis software and scripting (DIA-NN, Proteome Discoverer, R, Python).
• Excellent organizational, troubleshooting, and communication skills.
• Proven ability to work collaboratively across interdisciplinary teams.

Responsibilities

• Lead the design and execution of proteomics experiments (eg, TMT, DIA, DDA).
• Develop and implement automated workflows for sample prep, instrument scheduling, data acquisition, and analysis.
• Manage and maintain mass spectrometry instrumentation and preventive maintenance.
• Integrate laboratory robotics and liquid handling into proteomics pipelines.
• Develop, optimize, and troubleshoot sample prep workflows including whole cell proteomics and interactome analyses.
• Analyze data using advanced pipelines and support biological interpretation.
• Train and mentor junior staff and contribute to continuous improvement.
• Ensure compliance with lab safety, QC standards, and data integrity policies.
• Communicate with purchasing and negotiate with vendors.

Skills

Mass spectrometry

Proteomics

Data analysis

Laboratory automation

Instrument operation

Scripting (R/Python)

Education

Ph.D in biochemistry / analytical chemistry / bioengineering or related field

Tools

Thermo mass spectrometers

Bruker mass spectrometers

Job description

Dana-Farber Cancer Institute in Boston is seeking a Scientist I / Research Scientist to join the TPD Core. The role uses mass spectrometry to study proteome-wide responses to perturbations and contribute to projects on targeted protein degradation with emphasis on automation and workflow development.

You will lead experiments (TMT, DIA, DDA), maintain instruments, and collaborate across teams to advance cancer biology research while upholding data integrity and safety standards.