Senior Proteomics Technician: Mass Spec & Cells

Dana-Farber Cancer Institute; Boston, Northern (MA, KY); Hybrid; USD 52,000 - 57,000; Full time

Job summary

The Dana-Farber Cancer Institute's TPD Proteomics Core in the Fischer Lab seeks a Senior Research Technician to apply mass spectrometry-based methods to profile cellular proteomes under stimuli. You will work with technicians, scientists, postdocs, and students on projects centered on targeted protein degradation as a novel therapeutic approach.

Located in Boston, you will contribute to proteomics workflows, QC, data analysis, and protocol improvements while maintaining rigorous lab standards

Qualifications

• Bachelor’s degree in biology, chemistry, or related field required.
• 1–4 years in mass spectrometry or molecular biology lab (academic or industry).
• Experience operating Thermo and/or Bruker mass spectrometers required.
• Experience with mammalian cell culture and proteomics sample prep preferred.
• Experience in MS data analysis and quantitative methods.
• Knowledge of statistics and R programming preferred.
• Familiarity with Proteome Discoverer, DIANN, and Spectronaut

Responsibilities

• Perform cell culture and drug treatments as part of the core team.
• Prepare proteomics samples including lysis, digestion, cleanup, and labeling.
• Run LC-MS samples on Orbitrap/timsTOF following SOPs and QC checks.
• Maintain lab notebooks and sample metadata accurately.
• Collaborate with core users to ensure timely sample processing.
• Help implement new protocols and train junior staff.
• Maintain lab supplies and liaise with purchasing/vendors.

Skills

Mass spectrometry

Cell culture

Data analysis

R programming

Education

Bachelor's degree in biology, chemistry, or related field

Tools

Thermo mass spectrometers

Bruker mass spectrometers

Proteome Discoverer

DIANN

Spectronaut

S-Trap

SP3

TMT

Job description

The Dana-Farber Cancer Institute's TPD Proteomics Core in the Fischer Lab seeks a Senior Research Technician to apply mass spectrometry-based methods to profile cellular proteomes under stimuli. You will work with technicians, scientists, postdocs, and students on projects centered on targeted protein degradation as a novel therapeutic approach.

Located in Boston, you will contribute to proteomics workflows, QC, data analysis, and protocol improvements while maintaining rigorous lab standards