Pharma Analytical Chemist — Onsite RNA/LNP QC & HPLC/LC-MS

Cogent Scientific; Watertown (MA); On-site; USD 90,000 - 110,000; Full time

Benefits offered by this job

Medical/dental/vision benefits

401(k)

Parental leave

Paid holidays and PTO

Job summary

Cogent Scientific is seeking a Pharma Analytical Chemist to develop and validate analytical methods for RNA quantification and lipid nanoparticle analysis. The role involves LC-MS/MS method development, QC testing of LNP batches, and cross-functional data interpretation.

The ideal candidate has a BS or MS in a relevant field with 0–5 years of lab experience, strong communication, and teamwork skills. Onsite in Watertown, MA, with a day shift schedule.

Qualifications

• BS or MS in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, Bioengineering, Molecular Biology, or related discipline.
• 0–5 years of laboratory experience in analytical sciences, drug delivery, biologics, or nucleic acid therapeutics.
• Excellent communication skills – verbal and written.
• Ability to work independently and in a team.
• Strong problem-solving skills and learning agility.
• Leadership and communication skills for a fast-paced multidisciplinary environment.

Responsibilities

• Develop, optimize, and validate HPLC-based methods for RNA quantification and purity assessment.
• Develop and troubleshoot LC-MS/MS methods for LNP lipid components and RNA quantification.
• Perform routine QC testing of LNP batches, including lipid quantification and RNA integrity.
• Determine encapsulation efficiency using orthogonal methods (HPLC, AEX, RiboGreen).
• Perform separations-based characterization using SEC, HIC, AEX/IEX, and RPLC.
• Support protein and conjugate characterization using CE-SDS, cIEF, and LC-MS peptide mapping.
• Investigate and troubleshoot chromatographic performance and instrument issues.
• Analyze data, identify trends, and present findings to the team.

Skills

Communication

Teamwork

Problem solving

Learning agility

Leadership

Education

BS or MS in Chemistry / Biochemistry / Pharmaceutical Sciences / related

Tools

HPLC

LC-MS/MS

SEC

HIC

AEX/ IEX

RPLC

CE-SDS

cIEF

LC-MS peptide mapping

Job description

Cogent Scientific is seeking a Pharma Analytical Chemist to develop and validate analytical methods for RNA quantification and lipid nanoparticle analysis. The role involves LC-MS/MS method development, QC testing of LNP batches, and cross-functional data interpretation.

The ideal candidate has a BS or MS in a relevant field with 0–5 years of lab experience, strong communication, and teamwork skills. Onsite in Watertown, MA, with a day shift schedule.