Peptide Upstream Scientist - Process Transfer & Scale-Up

Eli Lilly and Company; Lebanon (IN); On-site; USD 66,000 - 172,000; Full time

Job summary

Eli Lilly and Company in Lebanon, Indiana, is seeking a Mixed Modality (Peptide Upstream) Scientist to help transfer peptide upstream processes from development labs to pilot plant operations, enabling grams-to-kilogram scale clinical supply.

The role requires a B.S./M.S. in chemistry and 3+ years in peptide chemistry, with SPPS experience preferred; you will document tech transfers, generate batch records, and work across teams to enable startup readiness.

Qualifications

• 3+ years of experience in peptide chemistry and/or manufacturing environments involving synthetic peptide API or drug substance
• Solid phase peptide synthesis is preferred
• Authorized to work in the United States on a full‑time basis; Lilly will not sponsor work authorization or visas

Responsibilities

• Perform synthetic peptide chemistry and assess synthetic routes from early phase process research and development labs.
• Familiarity with peptide upstream procedures such as SPPS and Cleavage & Precipitation.
• Evaluate safety of incoming procedures in collaboration with safety group and process engineering.
• Order and stage chemicals.
• Obtain reference materials and participate in setting up analytical methods.
• Reprocess and analyze analytical data to make fact-based decisions.
• Summarize and present chemistry and challenges.
• Ensure plant readiness of process steps including SPPS and Cleavage & Precipitation at the Lilly Medicine Foundry.
• Perform tests of key raw materials and document definitive lab trials of processes.
• Maintain organized lab notebooks for technical packages and transfers.
• Author and review technical documents including tech transfer plans and SOPs.
• Apply scientific knowledge to identify improvements and implement new technologies.
• Support troubleshooting and CAPAs with cross-functional teams

Skills

Peptide chemistry

SPPS

HPLC/UPLC

LC-MS

GC

NMR

Education

B.S./M.S. in chemistry

Job description

Eli Lilly and Company in Lebanon, Indiana, is seeking a Mixed Modality (Peptide Upstream) Scientist to help transfer peptide upstream processes from development labs to pilot plant operations, enabling grams-to-kilogram scale clinical supply.

The role requires a B.S./M.S. in chemistry and 3+ years in peptide chemistry, with SPPS experience preferred; you will document tech transfers, generate batch records, and work across teams to enable startup readiness.