Mixed Modality Peptide Upstream Scientist

100 Eli Lilly and Company; United States; On-site; USD 66,000 - 172,000; Full time

Job summary

Lilly, a global healthcare leader based in Indianapolis, Indiana, seeks a Mixed Modality (Peptide Upstream) Scientist to transfer peptide upstream processes from development labs to pilot plant operations and enable early‑phase cGMP manufacturing. The role supports kilo‑scale and isolator production environments, documenting tech transfers and enabling plant readiness.

Responsibilities include evaluating synthesis routes, ensuring safety, and collaborating across teams to drive process

Qualifications

• B.S. or M.S. in chemistry, chemical engineering, or related field.
• 3+ years of experience in peptide chemistry and/or manufacturing environments involving synthetic peptide API or drug substance.
• Solid phase peptide synthesis is preferred.
• Qualified applicants must be authorized to work in the United States on a full‑time basis.

Responsibilities

• Synthetically evaluate and facilitate transfer of peptide upstream manufacturing processes from development labs to pilot plant operations.
• Perform synthetic peptide chemistry and assess routes from early phase process research labs.
• Evaluate safety of incoming procedures with safety group and process engineering.
• Maintain organized lab notebooks and document technical transfers and replication packages.
• Prepare and review tech transfer plans, SOPs, batch records, and deviation reports.

Skills

Peptide chemistry

SPPS

Scale-up

Cross-functional teamwork

Education

B.S./M.S. in chemistry

Tools

HPLC/UPLC

LC‑MS

NMR

Job description

Lilly, a global healthcare leader based in Indianapolis, Indiana, seeks a Mixed Modality (Peptide Upstream) Scientist to transfer peptide upstream processes from development labs to pilot plant operations and enable early‑phase cGMP manufacturing. The role supports kilo‑scale and isolator production environments, documenting tech transfers and enabling plant readiness.

Responsibilities include evaluating synthesis routes, ensuring safety, and collaborating across teams to drive process