LC-MS Scientist: siRNA Impurity & Method Development

Pace® Labs; Cambridge (MA); On-site; USD 92,000 - 95,000; Full time

Benefits offered by this job

Competitive salaries

Medical

Dental vision

401K retirement savings plan (100%vest

Life

Disability and voluntary benefits

Paid time off for holiday, sick andvac

HSA

Wellness program

Flexible spending accounts

Tuition reimbursement

Employee Assistance program

Parental leave

Optional legal coverage and ID theft

Job summary

Pace® Labs in Cambridge, MA seeks a Scientist to perform advanced analytical development with hands-on operation of High-Resolution LC-MS. You will develop and optimize HPLC and MS-based methods for siRNA identification, characterization, and impurity profiling of molecules, formulations, and raw materials.

Requires a Bachelor's or Master’s in Chemistry/Biology and 2–4 years in a GMP lab; strong organization, communication, and multitasking skills are essential.

Qualifications

• Bachelor's or Master's degree in Chemistry, Biology, or related field.
• 2-4 years of laboratory experience, GMP environment preferred.
• Excellent organizational and communication skills; detail-oriented.

Responsibilities

• Hands-on bench work using the High-Resolution LC-MS.
• Development of chromatographic methods (HPLC) and mass spectrometric based assays for identification, characterization, and impurity determination of siRNA.
• Develop strategies for impurity profiling of new development candidates and raw materials.
• Author method development and qualification reports and SOP's for test methods.
• Evaluate suitability of new methods, and assist method qualification and validation.
• Contribute data to lead candidate testing, stability sample monitoring, OOS/deviation investigation and regulatory filing.
• Understand and apply advanced scientific principles, theories, concepts, practices and standards to process and analytical development.
• Follow training to independently operate instruments and carry out routine and non-routine analyses.
• Collaborate with internal and external teams to support project goals and meet research timelines.

Skills

LC-MS

HPLC

Method development

Data analysis

Scientific writing

Education

Bachelor's or Master's in Chemistry, Biology, or related field

Tools

Agilent Q-ToF

MassHunter

Office 365

Job description

Pace® Labs in Cambridge, MA seeks a Scientist to perform advanced analytical development with hands-on operation of High-Resolution LC-MS. You will develop and optimize HPLC and MS-based methods for siRNA identification, characterization, and impurity profiling of molecules, formulations, and raw materials.

Requires a Bachelor's or Master’s in Chemistry/Biology and 2–4 years in a GMP lab; strong organization, communication, and multitasking skills are essential.