LC-MS Scientist for ADC Bioconjugates

Yoh, A Day & Zimmermann Company; Bristol Township (Bucks County); In loco; USD 43.000 - 62.000; Tempo pieno

Vantaggi offerti da questo lavoro

Medical, Prescription, Dental & Vision

Health Savings Account (HSA)

Life & Disability Insurance

401K Retirement Savings Plan

Direct Deposit & weekly epayroll

Referral Bonus Programs

Certification and training

Descrizione del lavoro

Yoh Life Sciences in Bristol, PA is seeking a Mass Spectrometry Scientist to serve as a technical expert in mass spectrometry-based characterization and method development across process development and CMC activities.

The successful candidate will develop LC-MS methods for conjugate characterization of ADCs, oligonucleotide conjugates, radioconjugates, and other complex bioconjugates, and will design MS studies for intact proteins, peptides, and related species.

Competenze

• PhD in Analytical Chemistry or related field, or MS with 2+ years of relevant experience.
• Experience with LC-MS characterization of biologics, ADCs, or related conjugates.
• Hands-on experience with high-resolution mass spectrometry and data interpretation.

Mansioni

• Lead development, optimization, and transfer of LC-MS methods for ADCs and related bioconjugates.
• Design and execute MS studies for characterization of intact proteins/antibodies and related species.
• Perform DAR analysis, peptide mapping, PTM identification, and linker-payload analysis.
• Support regulatory submissions and IND/BLA/IMPD analytical sections.
• Develop robust sample prep workflows for LC-MS analyses of proteins and conjugates.
• Interpret complex datasets and communicate findings to cross-functional teams.
• Support process development and manufacturing deviations and product quality assessments.

Conoscenze

LC-MS analysis

Biologics characterization

Data analysis

High-resolution MS

Formazione

PhD in Analytical Chemistry

MS in Chemistry/related

Strumenti

Waters Connect

MassLynx

Descrizione del lavoro

Yoh Life Sciences in Bristol, PA is seeking a Mass Spectrometry Scientist to serve as a technical expert in mass spectrometry-based characterization and method development across process development and CMC activities.

The successful candidate will develop LC-MS methods for conjugate characterization of ADCs, oligonucleotide conjugates, radioconjugates, and other complex bioconjugates, and will design MS studies for intact proteins, peptides, and related species.