Genome Engineering Scientist — Therapeutic Editing

Energy Jobline ZR; New York (NY); On-site; USD 120,000 - 190,000; Full time

Job summary

Energy Jobline ZR in New York, NY is seeking a Scientist - Genome Engineer to design, build, and validate genome editing approaches in human cellular disease models. This foundational hire will shape the platform, lab, and scientific culture, collaborating directly with the founding team. The role requires leadership, independent work, and the ability to drive IND-enabling studies and future patent filings.

Qualifications

• PhD in genetics, molecular biology, bioengineering, genome engineering or closely related field.
• Hands-on expertise with precision genome editing tools: CRISPR-Cas nucleases, base editors, prime editors, and the design and screening workflows around them.
• Demonstrated experience with multiple delivery systems.
• Experience editing primary cells or therapeutically relevant cell types with quantitative readouts.

Responsibilities

• Design and execute on multiple precision editing strategies.
• Build and screen libraries; optimize editing efficiency, purity and product outcome in primary cells and relevant disease models.
• Develop and compare delivery approaches across viral and non-viral delivery systems.
• Run specificity and safety assessment: off-target nomination and validation, translocation and large-deletion analysis.
• Own experimental design, data analysis and documentation to IND-enabling and patent-support.
• Manage additional team members, equipment, protocols, vendor relationships.

Skills

Experimental design

Data analysis

Independent work

Communication skills

Team leadership

Education

PhD in genetics

Tools

CRISPR-Cas

Base editors

Prime editors

Delivery systems

Job description

Energy Jobline ZR in New York, NY is seeking a Scientist - Genome Engineer to design, build, and validate genome editing approaches in human cellular disease models. This foundational hire will shape the platform, lab, and scientific culture, collaborating directly with the founding team. The role requires leadership, independent work, and the ability to drive IND-enabling studies and future patent filings.