Cellular Pharmacology Scientist, DAC Screening & Assays

Nurix Therapeutics; Brisbane (CA); On-site; USD 127,000 - 143,000; Full time

Job summary

Nurix Therapeutics is seeking a hands-on in vitro pharmacology scientist to design and execute cellular assays that characterize DAC activity and degradation. The role involves building assay cascades from primary screening through mechanistic pharmacological characterization and coordinating with discovery biology, conjugation chemistry, and automation teams.

The successful candidate will design, execute, and analyze mammalian cell-based assays, work with antibody binding and intracellular drug

Qualifications

• Ph.D. in a relevant scientific field with strong academic record or MS with 6+ years industry experience.
• Experience designing and setting up in vitro pharmacology studies and screening cascades.
• Hands-on mammalian cell culture and quantitative cellular assay execution and reporting.
• Familiarity with mechanistic assays and automation workflows.

Responsibilities

• Design, build, and optimize in vitro pharmacology assay cascades for DACs and biologics.
• Develop and perform cell-based assays to characterize DAC activity and degradation.
• Maintain mammalian cell lines and execute quantitative assays independently.
• Collaborate across discovery biology, chemistry, and DMPK to advance candidates.
• Present results and stay current with ADC/DAC literature and trends.

Skills

In vitro pharmacology

Mammalian cell culture

Assay development

Data analysis

Automation/liquid handling

Team collaboration

Education

Ph.D. in Biochemistry/Pharmacology/Biology

MS with 6+ years industry experience

Tools

Automation equipment

Luminescence assays

Cell culture facilities

Job description

Nurix Therapeutics is seeking a hands-on in vitro pharmacology scientist to design and execute cellular assays that characterize DAC activity and degradation. The role involves building assay cascades from primary screening through mechanistic pharmacological characterization and coordinating with discovery biology, conjugation chemistry, and automation teams.

The successful candidate will design, execute, and analyze mammalian cell-based assays, work with antibody binding and intracellular drug