Senior Scientist, Degrader Antibody Conjugates Pharmacology

NURIX; San Francisco (CA); On-site; USD 180,000 - 250,000; Full time

Job summary

Nurix Therapeutics seeks a scientific leader to define and drive our in vitro screening and pharmacological characterization for Degrader Antibody Conjugates (DACs). This hands-on leadership role requires building assays, interpreting data, and guiding cross-functional teams from primary screening through candidate selection.

The ideal candidate will design, execute, and analyze cellular assays to characterize DAC activity, work with discovery biology, chemistry, and DMPK, and mentor scientists

Qualifications

• PhD in Biochemistry, Pharmacology, Biology or related field with 4+ years of post-graduate experience, or MS with 8+ years in industry.
• Demonstrated experience designing and executing in vitro pharmacology studies and screening cascades, preferably in ADC/DAC fields.
• Leadership in a matrixed, cross-functional environment with ability to influence, align and drive teams.

Responsibilities

• Design and build the in vitro pharmacology and screening framework for DACs and biologics from primary screening through mechanistic characterization.
• Lead and influence a matrixed organization, partnering with discovery biology, chemistry, analytics, DMPK, and automation to advance programs.
• Conduct and analyze cell-based assays to characterize DAC and biologic activity, including binding, engagement, and degradation measures.
• Provide scientific judgment on assay strategy, data interpretation, and go/no-go recommendations.

Skills

in vitro pharmacology

ADC/DAC biology

cell culture

matrixed leadership

data interpretation

presentations

automation workflows

Education

PhD in Biochemistry

MS in Biology

Tools

Automation equipment

Liquid handling systems

Job description

Nurix Therapeutics seeks a scientific leader to define and drive our in vitro screening and pharmacological characterization for Degrader Antibody Conjugates (DACs). This hands-on leadership role requires building assays, interpreting data, and guiding cross-functional teams from primary screening through candidate selection.

The ideal candidate will design, execute, and analyze cellular assays to characterize DAC activity, work with discovery biology, chemistry, and DMPK, and mentor scientists