Serif Biomedicines | Cambridge, MA Associate Scientist, Bioanalytical Assays

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 96,000 - 127,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Job summary

Serif Biomedicines in Cambridge, MA is seeking an experienced Associate Scientist to drive bio-analytical assays for a novel DNA platform. The role involves working with in vitro and in vivo assays, applying rigorous scientific methods, and collaborating across a fast-paced, entrepreneurial team.

You will execute and optimize assays (ELISA, qPCR, ddPCR), contribute to platform development, and communicate results clearly.

Qualifications

• Masters or BS in a relevant discipline with 6+ years of industry experience.
• Deep expertise in ex-vivo analytical assays such as ELISA, MSD, qPCR, ddPCR.
• Hands-on experience with multi-parameter flow cytometry, including panel design, compensation, and analysis.
• Experience with transfection methods in human and NHP PBMCs.
• Proficiency in processing tissues and isolation of various cell types (hepatocytes, immune cells etc.) from mice and NHPs.
• Prior experience in nucleic acid therapeutics or LNPs is a plus.
• Experience with histological techniques (IHC/IF, ISH, H&E).
• Strong communication, interpersonal, organizational, analytical, and problem-solving skills.

Responsibilities

• Execute and analyze bioassays to assess efficacy, safety and biodistribution in rodents and NHPs.
• Contribute to scientific and technical perspectives to advance platform development.
• Develop, optimize, and execute ligand binding assays for studies in-house and at CROs.
• Communicate experimental findings orally, in writing, and visually.
• Work independently and in a multidisciplinary team.

Skills

Bioanalytical assays

ELISA

MSD

qPCR

ddPCR

Flow cytometry

PBMC transfection

Tissue processing

Nucleic acid therapeutics

Histology techniques

Communication skills

Team collaboration

Education

Master's or BS in a relevant discipline

Job description

Associate Scientist, Bioanalytical Assays

Cambridge, MA USA

Company Summary

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.

Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary

We are searching for an experienced Associate Scientist to drive bio-analytical assays for a novel DNA platform. More broadly, we are looking for an individual who enjoys working with in vitro and in vivo assays, and brings scientific rigor, intellectual curiosity, enthusiasm, and a desire to innovate new nucleic acid therapeutics. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment, working both independently and as part of a highly collaborative and rapidly growing team.

Key Responsibilities

• Execution and analysis of bioassays, to assess efficacy, safety and biodistribution of novel nucleic acid therapeutics in rodents and NHPs
• Contribute to scientific and technical perspectives to advance platform development.
• Develop, optimize, and execute ligand binding assays to support studies in-house and at CROs.
• Effectively communicate experimental findings in oral, written, and visual formats.
• Work independently and collaboratively in a multidisciplinary team environment.

Qualifications

• Masters or BS in relevant discipline with 6+ years of industry experience. Level will be based on experience.
• Deep expertise in ex-vivo analytical assays such as ELISA, MSD, qPCR, ddPCR, etc.
• Hands-on experience with multi-parameter flow-cytometry, including panel design, compensation, and analysis.
• Experience with various transfection methods in human and NHP PBMCs is preferred
• Proficiency in processing tissues and isolation of various cell types (hepatocytes, immune cells etc.) from mice and NHPs
• Prior experience in nucleic acid therapeutics or LNPs is a plus
• Experience with histological techniques (IHC/IF, ISH, H&E, etc.) analysis is a plus.
• Strong communication, interpersonal, organizational, analytical, and problem-solving skills.
• The successful candidate will be expected to demonstrate flexibility in supporting the accelerated timelines associated with data generation, analysis, and reporting for in vivo studies.
• Ability to thrive in a fast-paced, multidisciplinary, and rapidly growing biotech environment.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

The salary range for this role is $96,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future.