ADME Scientist, Antibody-Oligonucleotide Conjugates

Novartis Group Companies; San Diego (CA); On-site; USD 109,000 - 202,000; Full time

Benefits offered by this job

Health, life & disability benefits

401(k) with company match

Generous vacation and leaves

Job summary

Novartis Group Companies is seeking a skilled ADME scientist for a laboratory-based role in San Diego, focusing on antibody-oligonucleotide conjugates and related modalities. You will perform ADME/biotransformation workflows, apply immunoprecipitation, and use LC-MS/MS/HRMS to characterize conjugates in biological matrices.

You will design and interpret in vitro and in vivo studies, collaborating with discovery and development teams to support translational decision-making and candidate

Qualifications

• PhD/MSc/BSc with industry ADME or biologics research.
• Hands-on experience with immunoprecipitation and affinity capture.
• Experience with LC-MS/MS or HRMS workflows for conjugates.

Responsibilities

• Develop and execute ADME/biotransformation workflows for antibody-oligonucleotide conjugates.
• Apply immunoprecipitation and affinity capture to enrich conjugates from biological samples.
• Use LC-MS/MS and HRMS to assess conjugate integrity, stability, and tissue distribution.
• Design and interpret in vitro and in vivo studies linking data to PK/PD and candidate selection.
• Provide ADME input to project strategy in cross-functional teams.
• Prepare study plans, reports, regulatory content, and presentations.
• Resolve assay/workflow challenges to improve data quality and throughput.
• Maintain high standards of documentation, data integrity, safety, and compliance.

Skills

ADME

LC-MS/MS

Immunoprecipitation

Affinity capture

Biotransformation

Data interpretation

Communication

English fluency

Education

PhD in pharmaceutical sciences / biochemistry / analytical chemistry / pharmacology

MSc or BSc with relevant ADME in biologics experience

Tools

LC-MS/MS

HRMS

Biology sample prep

Job description

Novartis Group Companies is seeking a skilled ADME scientist for a laboratory-based role in San Diego, focusing on antibody-oligonucleotide conjugates and related modalities. You will perform ADME/biotransformation workflows, apply immunoprecipitation, and use LC-MS/MS/HRMS to characterize conjugates in biological matrices.

You will design and interpret in vitro and in vivo studies, collaborating with discovery and development teams to support translational decision-making and candidate