Senior Scientist, Oligonucleotide Conjugation & Bioconjugates

Amgen SA; Thousand Oaks (CA); On-site; USD 140,000 - 190,000; Full time

Benefits offered by this job

Total Rewards Plan

Stock-based incentives

Flexible work models

Retirement and Savings Plan

Health and welfare plans

Job summary

Amgen is seeking a Senior Scientist in Thousand Oaks, CA, to advance oligonucleotide conjugation strategies for siRNA-based therapeutics. You will design, synthesize, purify, and characterize conjugates, leading projects end-to-end while collaborating with biology, analytical, and translational teams.

The role calls for deep expertise in conjugation chemistry, analytical methods, and scalable processes, with opportunities to contribute to patents and publications in a dynamic preclinical setting.

Qualifications

• PhD with relevant biotech/pharma experience in oligonucleotide conjugation or, alternatively, Master’s with 2+ years industry experience in biotech/pharma with oligo conjugation work.
• Bachelor’s with 4+ years in biotech/pharma and oligonucleotide conjugation experience.

Responsibilities

• Design, synthesize, purify and characterize oligonucleotide conjugates and optimize protocols.
• Drive execution of conjugation projects from start to finish with hands-on synthesis and purification.
• Serve as SME in cross-functional meetings and train collaborators as needed.
• Prepare results for presentations, patents and publications.

Skills

Oligonucleotide conjugation

Conjugation chemistry

Bioconjugation techniques

Analytical chromatography

Automated oligonucleotide synthesizers

Teamwork & collaboration

Scientific communication

Education

Doctorate degree

Master’s degree in Chemistry/Biochemistry/Chemical Engineering

Bachelor’s degree in Chemistry/Biochemistry/Chemical Engineering

Tools

IEX

RP-HPLC

SEC

LC-MS

Automated oligonucleotide synthesizers

Job description

Amgen is seeking a Senior Scientist in Thousand Oaks, CA, to advance oligonucleotide conjugation strategies for siRNA-based therapeutics. You will design, synthesize, purify, and characterize conjugates, leading projects end-to-end while collaborating with biology, analytical, and translational teams.

The role calls for deep expertise in conjugation chemistry, analytical methods, and scalable processes, with opportunities to contribute to patents and publications in a dynamic preclinical setting.