Senior Scientist, PBPK/PBBM Modelling & Drug Development

TekWissen UK; Stone Cross; On-site; GBP 90,000 - 130,000; Full time

Job summary

TekWissen UK is seeking a Senior Scientist with expertise in PBPK and PBBM to support the development and optimization of innovative drug products across all stages of development. You will apply mechanistic modelling to understand how formulation, dissolution, physiology and clinical variables influence in vivo performance and patient outcomes.

The role requires collaboration with biopharmaceutics, formulation development and clinical pharmacology teams, plus contributions to regulatory

Qualifications

• PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or a related field; MSc with substantial relevant industrial PBPK/PBBM experience.
• Demonstrated expertise in PBPK, PBBM, pharmacometrics or model-informed drug development.
• Strong understanding of oral absorption, dissolution, permeability and biopharmaceutics.

Responsibilities

• Develop, verify and apply PBPK/PBBM models using platforms such as Simcyp, GastroPlus or equivalent.
• Support prediction of oral absorption, food effects, bioavailability, dissolution and virtual bioequivalence.
• Perform model calibration, sensitivity analyses and scenario testing.
• Collaborate with lab scientists to design in vitro studies supporting model development.
• Support development of dissolution methods and IVIV links.
• Communicate modelling outcomes in reports, presentations, regulatory documents and publications.
• Drive innovation in modelling methods, automation and data-driven approaches including AI/ML.

Skills

PBPK

PBBM

Pharmacometrics

Mechanistic modelling

MIDD

Oral absorption

Biopharmaceutics

Regulatory writing

Education

PhD in Pharmaceutical Sciences

MSc in a relevant field

Tools

Simcyp

GastroPlus

PK-Sim

Python

R

MATLAB

Job description

TekWissen UK is seeking a Senior Scientist with expertise in PBPK and PBBM to support the development and optimization of innovative drug products across all stages of development. You will apply mechanistic modelling to understand how formulation, dissolution, physiology and clinical variables influence in vivo performance and patient outcomes.

The role requires collaboration with biopharmaceutics, formulation development and clinical pharmacology teams, plus contributions to regulatory