Senior Scientist, PBPK/PBBM Modelling & Simulation

TekWissen UK; Newsham; On-site; GBP 70,000 - 100,000; Full time

Job summary

TekWissen is seeking a Senior Scientist in Biopharmaceutics Modelling & Simulation for a 12-month assignment in Sandwich, UK. You will lead PBPK and PBBM modelling efforts to understand drug substance properties, formulation design, dissolution, physiology and clinical variables affecting in vivo performance.

The role requires expertise in PBPK/PBBM, pharmacometrics and model-informed drug development, with collaboration across biopharmaceutics, formulation development, clinical pharmacology and

Qualifications

• PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or related field.
• For MSc candidates, substantial industrial PBPK, PBBM, pharmacometrics or model-informed drug development experience required.
• Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling or model-informed drug development.

Responsibilities

• Develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, GastroPlus or equivalent software.
• Support the prediction and assessment of oral absorption, food effect, bioavailability, dissolution and virtual bioequivalence.
• Perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to support project decisions.
• Collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and verification.
• Support the development of clinically relevant dissolution methods and in vitro–in vivo links where appropriate.
• Communicate modelling outcomes through technical reports, project team presentations, regulatory documents, and scientific publications.
• Contribute to innovation in modelling methodologies, automation, and data-driven approaches, including AI/ML-enabled predictive tools where appropriate.

Skills

PBPK modelling

PBBM modelling

Pharmacometrics

Mechanistic modelling

Oral absorption & dissolution

Scientific communication

Publications/Regulatory contributions

Model-informed drug development

Education

PhD in Pharmaceutical Sciences or Biopharmaceutics

MSc in Pharmaceutical Sciences or related field

Tools

Simcyp

GastroPlus

PK-Sim

Python

R

MATLAB

Job description

TekWissen is seeking a Senior Scientist in Biopharmaceutics Modelling & Simulation for a 12-month assignment in Sandwich, UK. You will lead PBPK and PBBM modelling efforts to understand drug substance properties, formulation design, dissolution, physiology and clinical variables affecting in vivo performance.

The role requires expertise in PBPK/PBBM, pharmacometrics and model-informed drug development, with collaboration across biopharmaceutics, formulation development, clinical pharmacology and