Senior Scientist, Biopharmaceutics Modelling & Simulation

TekWissen UK; Stone Cross; On-site; GBP 90,000 - 130,000; Full time

Job summary

TekWissen UK is seeking a Senior Scientist with expertise in PBPK and PBBM to support the development and optimization of innovative drug products across all stages of development. You will apply mechanistic modelling to understand how formulation, dissolution, physiology and clinical variables influence in vivo performance and patient outcomes.

The role requires collaboration with biopharmaceutics, formulation development and clinical pharmacology teams, plus contributions to regulatory

Qualifications

• PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or a related field; MSc with substantial relevant industrial PBPK/PBBM experience.
• Demonstrated expertise in PBPK, PBBM, pharmacometrics or model-informed drug development.
• Strong understanding of oral absorption, dissolution, permeability and biopharmaceutics.

Responsibilities

• Develop, verify and apply PBPK/PBBM models using platforms such as Simcyp, GastroPlus or equivalent.
• Support prediction of oral absorption, food effects, bioavailability, dissolution and virtual bioequivalence.
• Perform model calibration, sensitivity analyses and scenario testing.
• Collaborate with lab scientists to design in vitro studies supporting model development.
• Support development of dissolution methods and IVIV links.
• Communicate modelling outcomes in reports, presentations, regulatory documents and publications.
• Drive innovation in modelling methods, automation and data-driven approaches including AI/ML.

Skills

PBPK

PBBM

Pharmacometrics

Mechanistic modelling

MIDD

Oral absorption

Biopharmaceutics

Regulatory writing

Education

PhD in Pharmaceutical Sciences

MSc in a relevant field

Tools

Simcyp

GastroPlus

PK-Sim

Python

R

MATLAB

Job description

Job Title: Senior Scientist, Biopharmaceutics Modelling & Simulation

Location: Sandwich, UK

Duration: 12 Months

Overview:

TekWissen is a global workforce management provider throughout the UK, Europe and many other countries in the world. The below client is an American multinational pharmaceutical and biotechnology corporation.

Job Description:

Role Summary

• We are seeking a highly motivated Senior Scientist with expertise in Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutics Modelling (PBBM) to support the development and optimization of innovative drug products across all stages of development.
• The successful candidate will apply mechanistic modelling and simulation approaches to understand and predict the impact of drug substance properties, formulation design, dissolution, physiology, and clinical variables on in vivo performance and patient outcomes.
• The scientist will work within multidisciplinary project teams and collaborate closely with scientists in biopharmaceutics, formulation development, clinical pharmacology and PDM (Pharmacokinetics, Distribution and Metabolism) to support model-informed drug development and regulatory decision-making.

Key Responsibilities

• Develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, GastroPlus or equivalent software.
• Support the prediction and assessment of oral absorption, food effect, bioavailability, formulation bridging, dissolution and particle size specifications, and virtual bioequivalence.
• Perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to support project decisions.
• Collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and verification.
• Support the development of clinically relevant dissolution methods and in vitro-in vivo links where appropriate.
• Communicate modelling outcomes through technical reports, project team presentations, regulatory documents, and scientific publications.
• Contribute to innovation in modelling methodologies, automation, and data-driven approaches, including AI/ML-enabled predictive tools where appropriate.

Required Qualifications

• PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or a related scientific discipline. For MSc candidates, substantial relevant industrial experience in PBPK, PBBM, pharmacometrics, mechanistic modelling or model-informed drug development is required.
• Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development.
• Strong understanding of oral absorption, dissolution, permeability, biopharmaceutics, and pharmacokinetics.
• Experience with PBPK/PBBM modelling software such as Simcyp, GastroPlus, PK-Sim or similar platforms.
• Demonstrated ability to apply modelling to solve pharmaceutical development challenges.
• Strong written and verbal scientific communication skills.
• Evidence of scientific productivity through publications, presentations, technical reports or regulatory contributions.

Preferred Qualifications

• Experience supporting regulatory submissions involving PBPK or PBBM analyses.
• Experience with virtual bioequivalence or clinically relevant dissolution specifications.
• Working knowledge of Python, R, MATLAB, or other scientific programming tools.
• Experience applying machine learning or data science approaches to pharmaceutical development.
• Experience across multiple drug modalities, including poorly soluble compounds, enabling formulations, peptides, or complex dosage forms.

TekWissen® Group is an equal opportunity employer supporting workforce diversity.