Senior Scientist - PBPK/PBBM Modelling & Predictive Science

Cpl Life Sciences

England

On-site

GBP 60,000 - 95,000

Full time

2 days ago

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Job summary

Cpl Life Sciences is seeking a Senior Scientist to lead PBPK/PBBM modelling efforts across drug development programmes. You will apply mechanistic modelling to predict in vivo performance, inform formulation design, dissolution, and clinical variables, and collaborate with Biopharmaceutics, Formulation Development, Clinical Pharmacology, and PDM teams.

The role requires strong expertise in PBPK/PBBM, pharmacometrics, and platforms such as Simcyp, GastroPlus, or PK-Sim, with programming skills in

Qualifications

PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering, or related discipline.

Responsibilities

Develop and apply PBPK/PBBM models using platforms such as Simcyp, GastroPlus, or PK-Sim.
Support predictions of oral absorption, food effect, bioavailability, formulation bridging, and virtual bioequivalence.
Perform model calibration, sensitivity analyses, and scenario testing to support key project decisions.
Collaborate with laboratory scientists to design and interpret studies supporting model development.
Communicate modelling results through reports, presentations, publications, and regulatory documents.
Contribute to innovations in modelling, automation, and AI/ML-enabled predictive approaches.