Senior Scientist, Biopharmaceutics Modelling & Simulation

TekWissen UK; Newsham; On-site; GBP 70,000 - 100,000; Full time

Job summary

TekWissen is seeking a Senior Scientist in Biopharmaceutics Modelling & Simulation for a 12-month assignment in Sandwich, UK. You will lead PBPK and PBBM modelling efforts to understand drug substance properties, formulation design, dissolution, physiology and clinical variables affecting in vivo performance.

The role requires expertise in PBPK/PBBM, pharmacometrics and model-informed drug development, with collaboration across biopharmaceutics, formulation development, clinical pharmacology and

Qualifications

• PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or related field.
• For MSc candidates, substantial industrial PBPK, PBBM, pharmacometrics or model-informed drug development experience required.
• Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling or model-informed drug development.

Responsibilities

• Develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, GastroPlus or equivalent software.
• Support the prediction and assessment of oral absorption, food effect, bioavailability, dissolution and virtual bioequivalence.
• Perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to support project decisions.
• Collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and verification.
• Support the development of clinically relevant dissolution methods and in vitro–in vivo links where appropriate.
• Communicate modelling outcomes through technical reports, project team presentations, regulatory documents, and scientific publications.
• Contribute to innovation in modelling methodologies, automation, and data-driven approaches, including AI/ML-enabled predictive tools where appropriate.

Skills

PBPK modelling

PBBM modelling

Pharmacometrics

Mechanistic modelling

Oral absorption & dissolution

Scientific communication

Publications/Regulatory contributions

Model-informed drug development

Education

PhD in Pharmaceutical Sciences or Biopharmaceutics

MSc in Pharmaceutical Sciences or related field

Tools

Simcyp

GastroPlus

PK-Sim

Python

R

MATLAB

Job description

Job Title: Senior Scientist, Biopharmaceutics Modelling & Simulation

Location: Sandwich, UK

Duration: 12 Months

Overview:

TekWissen is a global workforce management provider throughout the UK, Europe and many other countries in the world. The below client is an American multinational pharmaceutical and biotechnology corporation.

Job Description:

Role Summary

• We are seeking a highly motivated Senior Scientist with expertise in Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutics Modelling (PBBM) to support the development and optimization of innovative drug products across all stages of development.
• The successful candidate will apply mechanistic modelling and simulation approaches to understand and predict the impact of drug substance properties, formulation design, dissolution, physiology, and clinical variables on in vivo performance and patient outcomes.
• The scientist will work within multidisciplinary project teams and collaborate closely with scientists in biopharmaceutics, formulation development, clinical pharmacology and PDM (Pharmacokinetics, Distribution and Metabolism) to support model-informed drug development and regulatory decision-making.

Key Responsibilities

• Develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, GastroPlus or equivalent software.
• Support the prediction and assessment of oral absorption, food effect, bioavailability, formulation bridging, dissolution and particle size specifications, and virtual bioequivalence.
• Perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to support project decisions.
• Collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and verification.
• Support the development of clinically relevant dissolution methods and in vitro-in vivo links where appropriate.
• Communicate modelling outcomes through technical reports, project team presentations, regulatory documents, and scientific publications.
• Contribute to innovation in modelling methodologies, automation, and data-driven approaches, including AI/ML-enabled predictive tools where appropriate.

Required Qualifications

• PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or a related scientific discipline. For MSc candidates, substantial relevant industrial experience in PBPK, PBBM, pharmacometrics, mechanistic modelling or model-informed drug development is required.
• Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development.
• Strong understanding of oral absorption, dissolution, permeability, biopharmaceutics, and pharmacokinetics.
• Experience with PBPK/PBBM modelling software such as Simcyp, GastroPlus, PK-Sim or similar platforms.
• Demonstrated ability to apply modelling to solve pharmaceutical development challenges.
• Strong written and verbal scientific communication skills.
• Evidence of scientific productivity through publications, presentations, technical reports or regulatory contributions.

Preferred Qualifications

• Experience supporting regulatory submissions involving PBPK or PBBM analyses.
• Experience with virtual bioequivalence or clinically relevant dissolution specifications.
• Working knowledge of Python, R, MATLAB, or other scientific programming tools.
• Experience applying machine learning or data science approaches to pharmaceutical development.
• Experience across multiple drug modalities, including poorly soluble compounds, enabling formulations, peptides, or complex dosage forms.

TekWissen® Group is an equal opportunity employer supporting workforce diversity.