Senior Scientist

Cpl Life Sciences; Newsham; On-site; GBP 60,000 - 90,000; Full time

Job summary

CPL Life Sciences is seeking a Senior Scientist with expertise in PBPK and PBBM modelling to support the development of innovative drug products across all stages of development within a global pharmaceutical organisation.

You will apply mechanistic modelling to predict in vivo performance, work with Biopharmaceutics, Formulation Development, Clinical Pharmacology, and PDM teams, and contribute to regulatory submissions and scientific publications.

Qualifications

• PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering, or related discipline.
• Strong expertise in PBPK, PBBM, pharmacometrics, or mechanistic modelling.
• Experience with Simcyp, GastroPlus, PK-Sim, or similar modelling platforms.

Responsibilities

• Develop and apply PBPK/PBBM models using platforms such as Simcyp, GastroPlus, or PK-Sim.
• Support predictions of oral absorption, food effect, bioavailability, formulation bridging, and virtual bioequivalence.
• Perform model calibration, sensitivity analyses, and scenario testing to support key project decisions.
• Collaborate with laboratory scientists to design and interpret studies supporting model development.
• Communicate modelling results through reports, presentations, publications, and regulatory documents.
• Contribute to innovations in modelling, automation, and AI/ML-enabled predictive approaches.

Skills

PBPK modelling

PBBM modelling

Pharmacokinetics

Education

PhD or MSc in Pharmaceutical Sciences or related field

Tools

Simcyp

GastroPlus

PK-Sim

Job description

We're seeking a talented Senior Scientist with expertise in PBPK and PBBM modelling to support the development of innovative drug products across all stages of development with a global pharmaceutical organisation

In this role, you'll apply mechanistic modelling and simulation approaches to predict and understand the impact of drug properties, formulation design, dissolution, physiology, and clinical variables on in vivo performance. You'll work closely with multidisciplinary teams across Biopharmaceutics, Formulation Development, Clinical Pharmacology, and PDM to drive model-informed development and regulatory decision-making.

Key Responsibilities

• Develop and apply PBPK/PBBM models using platforms such as Simcyp, GastroPlus, or PK-Sim.
• Support predictions of oral absorption, food effect, bioavailability, formulation bridging, and virtual bioequivalence.
• Perform model calibration, sensitivity analyses, and scenario testing to support key project decisions.
• Collaborate with laboratory scientists to design and interpret studies supporting model development.
• Communicate modelling results through reports, presentations, publications, and regulatory documents.
• Contribute to innovations in modelling, automation, and AI/ML-enabled predictive approaches.

What We're Looking For

• PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering, or related discipline.
• Strong expertise in PBPK, PBBM, pharmacometrics, or mechanistic modelling.
• Experience with Simcyp, GastroPlus, PK-Sim, or similar modelling platforms.
• Strong understanding of oral absorption, dissolution, permeability, and pharmacokinetics.
• Excellent communication skills and a track record of scientific contribution.

Desirable Experience

• PBPK/PBBM regulatory submissions.
• Virtual bioequivalence and clinically relevant dissolution specifications.
• Python, R, or MATLAB programming.
• Machine learning/data science applications in drug development.