Senior Scientist: PBPK/PBBM Modelling & Drug Development

Cpl Life Sciences

Newsham

On-site

GBP 60,000 - 90,000

Full time

11 days ago

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Job summary

CPL Life Sciences is seeking a Senior Scientist with expertise in PBPK and PBBM modelling to support the development of innovative drug products across all stages of development within a global pharmaceutical organisation.

You will apply mechanistic modelling to predict in vivo performance, work with Biopharmaceutics, Formulation Development, Clinical Pharmacology, and PDM teams, and contribute to regulatory submissions and scientific publications.

Qualifications

PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering, or related discipline.
Strong expertise in PBPK, PBBM, pharmacometrics, or mechanistic modelling.
Experience with Simcyp, GastroPlus, PK-Sim, or similar modelling platforms.

Responsibilities

Develop and apply PBPK/PBBM models using platforms such as Simcyp, GastroPlus, or PK-Sim.
Support predictions of oral absorption, food effect, bioavailability, formulation bridging, and virtual bioequivalence.
Perform model calibration, sensitivity analyses, and scenario testing to support key project decisions.
Collaborate with laboratory scientists to design and interpret studies supporting model development.
Communicate modelling results through reports, presentations, publications, and regulatory documents.
Contribute to innovations in modelling, automation, and AI/ML-enabled predictive approaches.