Senior Scientist: PBPK/PBBM Modelling & Simulation

Carbon 60; Stone Cross; On-site; GBP 28,000 - 32,000; Full time

Job summary

Carbon60 seeks a Senior Scientist with PBPK/PBBM modelling expertise to support drug product development across stages. You will develop mechanistic models to predict in vivo performance considering substance properties, formulation design, dissolution, physiology, and clinical variables.

You will collaborate with biopharmaceutics, formulation development, clinical pharmacology and PK/PD teams to support model-informed decisions and regulatory submissions.

Qualifications

• PhD or MSc in Pharmaceutical Sciences or related field. MSc candidates require substantial relevant industrial PBPK/PBBM experience.
• Expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling or model-informed drug development.
• Strong understanding of oral absorption, dissolution, permeability and pharmacokinetics.
• Experience with PBPK/PBBM software such as Simcyp, GastroPlus, PK-Sim or similar.
• Ability to apply modelling to solve pharmaceutical development challenges.
• Strong written and verbal scientific communication skills.
• Evidence of scientific productivity through publications or regulatory contributions.

Responsibilities

• Develop, verify, and apply PBBM and PBPK models using platforms like Simcyp, GastroPlus or equivalent.
• Support prediction of oral absorption, food effect, bioavailability and virtual bioequivalence.
• Perform model calibration, sensitivity analyses and scenario testing.
• Collaborate with lab scientists to design in vitro studies supporting model development.
• Assist development of dissolution methods and in vitro–in vivo links.
• Communicate modelling outcomes through reports, presentations and regulatory documents.
• Contribute to methodological innovation and AI/ML-enabled tools.

Skills

PBPK/PBBM modelling

Pharmacokinetics

Biopharmaceutics

Regulatory submissions

Education

PhD in Pharmaceutical Sciences

MSc in PBPK/Related

Tools

Simcyp

GastroPlus

PK-Sim

Job description

Carbon60 seeks a Senior Scientist with PBPK/PBBM modelling expertise to support drug product development across stages. You will develop mechanistic models to predict in vivo performance considering substance properties, formulation design, dissolution, physiology, and clinical variables.

You will collaborate with biopharmaceutics, formulation development, clinical pharmacology and PK/PD teams to support model-informed decisions and regulatory submissions.