Senior PBPK/PBBM Modelling Scientist

Carbon; Stone Cross; On-site; GBP 28,000 - 32,000; Full time

Job summary

Carbon in Sandwich, Kent is seeking a Senior Scientist with PBPK and PBBM expertise to support the development and optimization of innovative drug products across all stages of development.

You will apply mechanistic modelling to understand the impact of drug properties, formulation design, dissolution, physiology, and clinical variables on in vivo performance and patient outcomes, coordinating with laboratory scientists and regulatory teams.

Qualifications

• PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or a related scientific discipline.
• Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development.
• Strong understanding of oral absorption, dissolution, permeability, biopharmaceutics, and pharmacokinetics.
• Experience with PBPK/PBBM modelling software such as Simcyp, GastroPlus, PK-Sim or similar platforms.
• Demonstrated ability to apply modelling to solve pharmaceutical development challenges.
• Strong written and verbal scientific communication skills.
• Evidence of scientific productivity through publications, presentations, technical reports or regulatory contributions.

Responsibilities

• Develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, GastroPlus or equivalent software.
• Support the prediction and assessment of oral absorption, food effect, bioavailability, formulation bridging, dissolution and particle size specifications, and virtual bioequivalence.
• Perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to support project decisions.
• Collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and verification.
• Support the development of clinically relevant dissolution methods and in vitro-in vivo links where appropriate.
• Communicate modelling outcomes through technical reports, project team presentations, regulatory documents, and scientific publications.
• Contribute to innovation in modelling methodologies, automation, and data-driven approaches, including AI/ML-enabled predictive tools where appropriate.

Skills

PBPK modelling

PBBM

Pharmacokinetics

Mechanistic modelling

Oral absorption

Model-informed drug development

Education

PhD or MSc in Pharmaceutical Sciences / Biopharmaceutics

Tools

Simcyp

GastroPlus

PK-Sim

Python

R

MATLAB

Job description

Carbon in Sandwich, Kent is seeking a Senior Scientist with PBPK and PBBM expertise to support the development and optimization of innovative drug products across all stages of development.

You will apply mechanistic modelling to understand the impact of drug properties, formulation design, dissolution, physiology, and clinical variables on in vivo performance and patient outcomes, coordinating with laboratory scientists and regulatory teams.