Senior Scientist I, Biopharma Characterization & MS

IMMUNOCORE LTD; Moreton Pinkney; On-site; GBP 65,000 - 90,000; Full time

Job summary

Immunocore Ltd in Oxford is seeking a Senior Scientist I - Characterisation to advance characterisation methods for biopharmaceutical products including LC-MS/MS peptide mapping and intact mass analysis. You will work across microbial and mammalian expression systems, drive testing programs, and contribute to GMP-aligned quality processes.

You will mentor peers, present findings to senior management, and collaborate across departments to enable development of ImmTAX products and other biologics.

Qualifications

• Essential: Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Essential: Experience of glycosylation analysis of recombinant proteins or antibodies.
• Essential: Independently coordinated extensive testing of protein biomolecules.
• Essential: Characterisation of proteins expressed in both microbial and mammalian systems.
• Essential: Understanding of expected post-translational modifications in biological systems.
• Essential: Worked in a bench-based biopharmaceutical laboratory environment.
• Essential: Established as an expert amongst peers in electrophoretic, chromatographic, mass spectrometry.
• Desirable: Experience of glycosylation analysis of recombinant proteins or antibodies.
• Desirable: Experience with GMP principles.
• Desirable: Presented at external conferences.
• Desirable: Led a small project team through change in practice.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates.
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information.
• Providing support on technical aspects to others.

Skills

Peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Assay development

Team collaboration

Scientific reporting

Project leadership

Education

BSc or MSc in biochemistry/biotechnology

PhD in related discipline

Tools

HPLC

LC-MS/MS

Chromatography

Electrophoresis

MS data analysis

Job description

Immunocore Ltd in Oxford is seeking a Senior Scientist I - Characterisation to advance characterisation methods for biopharmaceutical products including LC-MS/MS peptide mapping and intact mass analysis. You will work across microbial and mammalian expression systems, drive testing programs, and contribute to GMP-aligned quality processes.

You will mentor peers, present findings to senior management, and collaborate across departments to enable development of ImmTAX products and other biologics.