Senior Characterisation Scientist (Biologics)

IMMUNOCORE LTD; Waltham St. Lawrence; On-site; GBP 52,000 - 75,000; Full time

Job summary

Immunocore in Oxford is seeking a Senior Scientist I to lead biochemical characterisation and MS-based analyses of biopharmaceuticals. You will design and perform peptide mapping, intact mass analysis, and glycosylation studies to support CMC for ImmTAX products.

You will mentor peers, generate study protocols and reports, and contribute to process development and stability studies, ensuring adherence to EHS and GMP-like expectations in a dynamic biotech environment.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic, or mass spectrometry techniques.

Responsibilities

• Characterise drug substance and drug product using peptide mapping (LC-MS/MS) and mass spectrometry.
• Contribute to characterisation of proteins and biologics for CMC development.
• Design and carry out biochemical characterisation and stability studies.
• Draft study protocols and reports; present findings to teams and partners.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Post-translational modification

Bench-based lab work

Protein expression

Analytical techniques

Education

BSc./MSc in biochemistry/biotechnology

PhD (desirable)

Tools

LC-MS/MS

Electrophoretic/Chromatographic tools

Mass spectrometry instrumentation

Job description

Immunocore in Oxford is seeking a Senior Scientist I to lead biochemical characterisation and MS-based analyses of biopharmaceuticals. You will design and perform peptide mapping, intact mass analysis, and glycosylation studies to support CMC for ImmTAX products.

You will mentor peers, generate study protocols and reports, and contribute to process development and stability studies, ensuring adherence to EHS and GMP-like expectations in a dynamic biotech environment.