Lead Bioanalytical Method Development (LC-MS/MS)

Nexus Life Sciences; Nottingham; On-site; GBP 54,000 - 66,000; Full time

Job summary

Nexus Life Sciences is seeking an MS Method Development Lead in Nottingham to drive LCMSMS bioanalytical method development and validation under GxP standards.

The role combines technical expertise with team leadership, overseeing a M&D & Validation group and ensuring GLP/SOP compliance. You will mentor staff, support regulatory submissions, and drive continuous improvement across the lab.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimise analytical extraction techniques, chromatography methods, and LC columns.
• Mentoring the Method Development & Validation team.
• Ensure compliance with GLP, SOPs, and international guidelines.
• Troubleshoot analytical methods and recommend improvements.
• Oversee cost-effective laboratory operations and consumables.
• Write and approve Methods of Analysis and transfer validated methods.
• Support regulatory submissions and resolve regulatory queries.
• Conduct investigations, implement CAPAs, and drive continuous improvement.
• Prepare and ensure adherence to GLP SOPs.
• Lead team meetings and staff development sessions.

Skills

HPLC

UPLC

LCMSMS

Chromatography data systems

Method development

Validation

Protein precipitation

SPE

Liquid-Liquid extraction

GLP

Regulatory compliance

Communication

Leadership

Education

Biochemistry or Biomedical Science degree

Tools

Empower

MassLynx

Minitab

Job description

Nexus Life Sciences is seeking an MS Method Development Lead in Nottingham to drive LCMSMS bioanalytical method development and validation under GxP standards.

The role combines technical expertise with team leadership, overseeing a M&D & Validation group and ensuring GLP/SOP compliance. You will mentor staff, support regulatory submissions, and drive continuous improvement across the lab.