Lead LC-MS/MS Bioanalytical Method Development

Nexus Life Sciences; Sheffield; On-site; GBP 54,000 - 66,000; Full time

Benefits offered by this job

Leadership opportunity

Professional development

Collaborative culture

Innovative bioanalytical projects

Job summary

Nexus Life Sciences in the United Kingdom is seeking an MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. The role combines technical expertise and strong team leadership.

You will optimise extraction and chromatography, mentor the Method Development & Validation team, ensure GLP compliance, support regulatory submissions, and drive continuous improvement across the laboratory.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimise analytical extraction techniques, chromatography methods, and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure compliance with GLP, SOPs, and international guidelines.
• Troubleshoot analytical methods and recommend improvements.
• Oversee cost-effective laboratory operations and consumable spend.
• Write and approve Methods of Analysis and transfer validated methods to analytical teams.
• Support regulatory submissions and resolve regulatory queries.
• Conduct investigations, implement CAPAs, and drive continuous improvement.
• Prepare, review, and ensure adherence to GLP SOPs.
• Lead team meetings and staff development sessions.

Skills

HPLC

UPLC

LCMSMS

Chromatography

Method development

Validation

Troubleshooting

GLP

Communication

Leadership

Education

Biochemistry or related

Tools

Empower

MassLynx

Minitab

Job description

Nexus Life Sciences in the United Kingdom is seeking an MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. The role combines technical expertise and strong team leadership.

You will optimise extraction and chromatography, mentor the Method Development & Validation team, ensure GLP compliance, support regulatory submissions, and drive continuous improvement across the laboratory.