Lead Bioanalytical LC-MS/MS Method Development

Nexus Life Sciences; Chester; On-site; GBP 54,000 - 66,000; Full time

Job summary

Nexus Life Sciences is seeking an MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. This role combines technical leadership with team management to deliver compliant, robust assays.

You will champion method development, troubleshooting, and CAPA-driven improvements, guiding the team to optimise extractions, chromatography, and data systems while supporting regulatory submissions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Responsibilities

• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Skills

GxP laboratory experience

HPLC/LCMSMS

Method development

Method validation

Troubleshooting

Extraction techniques

GLP/regulatory knowledge

Leadership

Communication

Education

Biochemistry / Biomedical Science degree or related

Tools

Empower

MassLynx

DOE

Minitab

GC experience

Job description

Nexus Life Sciences is seeking an MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. This role combines technical leadership with team management to deliver compliant, robust assays.

You will champion method development, troubleshooting, and CAPA-driven improvements, guiding the team to optimise extractions, chromatography, and data systems while supporting regulatory submissions.