Lead LCMS/MS Bioanalytical Method Development

Nexus Life Sciences; Wolverhampton; On-site; GBP 36,000 - 60,000; Full time

Benefits offered by this job

Leadership opportunity

Professional development

Collaborative work culture

Cutting-edge lab environment

Job summary

Nexus Life Sciences seeks an MS Method Development Lead to drive LCMSMS bioanalytical method development and validation under GxP standards in a leading-edge laboratory in Wolverhampton, UK. The role combines deep technical work with team leadership and regulatory support.

The candidate will optimise extraction and chromatography methods, oversee a skilled Method Development & Validation team, and ensure GLP/SOP compliance while contributing to regulatory submissions and continuous improvement

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS and chromatography data systems.
• Proficiency in method development, optimisation and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and liquid-liquid extraction.
• Understanding of regulatory and GLP requirements.

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimise analytical extraction techniques, chromatography methods and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure GLP, SOPs and international guidelines compliance.
• Troubleshoot analytical methods and recommend improvements.
• Oversee cost-effective laboratory operations and consumables spend.
• Write and approve Methods of Analysis and transfer validated methods.
• Support regulatory submissions and respond to regulatory queries.
• Conduct investigations, implement CAPAs, and drive continuous improvement.
• Prepare, review and ensure adherence to GLP SOPs.
• Lead team meetings and staff development sessions.

Skills

GxP laboratory

Leadership

HPLC/UPLC

LCMSMS

Method development

Validation

Sample extraction

Regulatory knowledge

Data systems

Education

Biochemistry degree

Tools

Empower

MassLynx

DOE

Minitab

Job description

Nexus Life Sciences seeks an MS Method Development Lead to drive LCMSMS bioanalytical method development and validation under GxP standards in a leading-edge laboratory in Wolverhampton, UK. The role combines deep technical work with team leadership and regulatory support.

The candidate will optimise extraction and chromatography methods, oversee a skilled Method Development & Validation team, and ensure GLP/SOP compliance while contributing to regulatory submissions and continuous improvement