Lead LC-MS/MS Method Development & Validation

Nexus Life Sciences; West Midlands; On-site; GBP 54,000 - 66,000; Full time

Job summary

Nexus Life Sciences in the United Kingdom seeks an experienced MS Method Development Lead to drive development and validation of LCMS/MS bioanalytical methods under GxP standards. The role blends deep technical expertise with team leadership and cross-functional collaboration.

You will lead method development/validation, optimise LC methods and extractions, mentor the M&D team, ensure GLP/SOP adherence, support regulatory submissions, and pursue continuous improvement in a cutting-edge lab

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory with 2+ years in management.
• Expertise in method development, optimisation, and validation.

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimise extraction techniques, chromatography, and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure GLP, SOPs and international guidelines compliance.
• Troubleshoot methods and drive continuous improvements.
• Oversee cost-effective lab operations and consumables spend.
• Write and approve Methods of Analysis and transfer to teams.
• Support regulatory submissions and resolve queries.
• Conduct investigations, implement CAPAs, and lead staff development.

Skills

HPLC

UPLC

LCMS/MS

GxP experience

Method development

Validation

Leadership

Regulatory knowledge

Education

Biochemistry degree

Tools

Empower

MassLynx

Minitab

Job description

Nexus Life Sciences in the United Kingdom seeks an experienced MS Method Development Lead to drive development and validation of LCMS/MS bioanalytical methods under GxP standards. The role blends deep technical expertise with team leadership and cross-functional collaboration.

You will lead method development/validation, optimise LC methods and extractions, mentor the M&D team, ensure GLP/SOP adherence, support regulatory submissions, and pursue continuous improvement in a cutting-edge lab