Research Assistant (Postdoc)

Philipps-Universität Marburg; Marburg; On-site; EUR 55,000 - 75,000; Full time

Benefits offered by this job

Equal Pay under Hessian Collective

Public transport ticket

Career development training

Collaborative research environment

Professional development opportunities

Job summary

Philipps-Universität Marburg invites applications for a fulltime research position lasting three years, aimed at designing and cloning optical biosensors to study GPCR conformational dynamics, and validating them in living cells. The successful candidate will apply biosensors to characterize GPCR responses to ligands and mechanical signals, perform pharmacological assays in microtiter plates, and analyze large datasets.

MSc or PhD and strong English skills are required.

Qualifications

• MSc or PhD in life sciences or near completion of doctoral studies.
• Extensive experience in molecular biology techniques for cloning fusion proteins.
• Experience with GPCRs, G proteins, GRKs or arrestins.
• Experience in designing and validating biosensors in living cells is desirable.
• Excellent English language skills.

Responsibilities

• Design and cloning of optical biosensors to measure GPCR conformational dynamics.
• Validate optical biosensors in living cells.
• Characterize GPCR responses to ligands and mechanical signals using biosensors.
• Design and perform pharmacological assays in microtiter plates (≥ 96-well).
• Analyze and visualize large pharmacological datasets.
• Perform structural modeling of GPCR-ligand interactions.

Skills

Molecular biology techniques

GPCR related research questions

Pharmacological assays in living cells

Biosensor design and validation

Very good English skills

Education

MSc degree or PhD in life sciences

Job description

The position is offered for a period of 3 years, if no former times of qualification must be considered. The starting date is as soon as possible. The position is fulltime with salary and benefits commensurate with a public service position in the state Hesse, Germany (TV-H E 13).

Tasks

• design and cloning of optical biosensors to measure conformational dynamics of G protein-coupled receptors (GPCRs)
• validation of optical biosensors in living cells
• application of optical biosensors to characterize GPCRs responses to ligand and mechanical signals
• design and performance of pharmacological, cell biological assays in microtiter plates (≥ 96-well)
• analysis and visualisation of large pharmacological datasets
• Structural modeling of GPCR-ligand interactions

The position will be filled by a temporary contract that is limited to the period which is necessary to gain further scientific expertise (such as the preparation for a subsequent qualification period). Within the entrusted tasks the opportunity for independent scientific work to obtain further personal qualification is given. The limitation complies with Section 2 (1) of the German Academic Fixed-Term Contract Act (WissZeitVG).

Profile

• MSc degree or equivalent and a Ph.D. in the life sciences or evidence of near completion of doctoral studies
• extensive experience in molecular biology techniques required for the cloning of new fusion proteins
• extensive experience in performing pharmacological assays in living cells in microtiter plate format (≥ 96-well)
• previous work on GPCR, G protein, GRK or arrestin related research questions
• experience in the design and validation of new biosensors used in living cells is desireable
• very good English skills

We offer

• equal Pay according to the Hesse Collective Agreement
• ticket for free use of public transport in the state Hesse, Germany
• career development training for junior scientists including postdoctoral researchers
• A collaborative, innovative, and supportive research environment
• Professional development opportunities, including training, coaching, and mentoring

Contact for more Information

Lilli Backhaus

[phone]

[e-mail]

We support women and strongly encourage them to apply. In areas where women are underrepresented, female applicants will be preferred in case of equal qualifications. As a certified family-friendly university, we support our employees in balancing family and career. A reduction of working time is possible. Applicants with a disability as discribed in the Social Security Code (Section 2(2) and (3) of Book IX of the Social Security Code (SGB IX)) will be preferred in case of equal qualifications. Application and interview costs can not be refunded.