Postdoc position (f/m/d)

Universitätsmedizin Göttingen; Niedersachsen; On-site; EUR 52,000 - 70,000; Full time

Job summary

Universitätsmedizin Göttingen sucht eine/n Postdoc (f/m/d) im Institut für Auditorische Neurowissenschaften. Vollzeit, 38,5 Stunden/Woche, zunächst befristet bis 31.12.2028. Bezahlung nach TV-L.

Standort Göttingen. Sie arbeiten an der in silico/experimentell integrierten Charakterisierung von Channelrhodopsin-Varianten, inkl. Protein-Expression, Reinigungs- und Analyseschritten, Kryo-EM, Konfokalmikroskopie und Dateninterpretation.

Qualifications

• Ausgezeichnete und hochmotivierte Bewerber/in mit starkem Hintergrund in der strukturellen und funktionellen Charakterisierung von Membrantransportproteinen.
• Fachkenntnisse in Strukturbiologie; idealerweise Bioinformatikkenntnisse sowie Patch-Clamp-Messungen oder datengetriebenes Protein-Design.
• Erfahrung in grundlegenden Molekularbiologie-Techniken (PCR, Klonierung etc.).

Responsibilities

• Tiefgehende strukturelle und funktionelle Charakterisierung optimierter Channelrhodopsin-Varianten.
• Aufreinigung rekombinanter Proteine; Bestimmung der Proteinstabilität; SDS-PAGE/Blue Native PAGE.
• Kryo-EM (Titan Krios G4); Hochdurchsatz-Spinning-Disc-Konfokalmikroskopie (CQ1).
• Datenanalyse; interdisziplinäre Zusammenarbeit im Labor.

Skills

Strukturelle Biologie

Bioinformatik

Patch Clamp

Protein-Design

Python

Teamfähigkeit

Kommunikation

Tools

Cryo-EM

Prometheus NT.48

SDS-PAGE

Blue Native PAGE

Titan Krios

CQ1 Confocal

Job description

The University Medical Center Göttingen (UMG) unites the Medical Faculty of the Georg-August University and the University Hospital in an integration model. With around 9,700 employees, the UMG and its subsidiaries are one of the largest employers in the region. Our clinics and institutes stand for high-quality patient care, excellent research, modern teaching and transfer of innovative technology.

Göttingen as a city of science is located in the center of Germany and the University Medical Center Göttingen is integrated into an attractive network of university and non-university scientific institutions.

The Institut für Auditorische Neurowissenschaften of the University Medical Center Göttingen is looking for a new position for the earliest start date

Postdoc position (f/m/d)

full time, with 38,5 hours per week, initially limited until 31.12.2028

Remuneration according to TV-L

The Göttingen Campus is hosting numerous prestigious and internationally renowned research institutions. This includes the University and its Medical Center, two life science Max Planck Institutes, the European Neuroscience Institute, and the German Primate Center. The Institute for Auditory Neuroscience & InnerEarLab is tightly integrated in the Campus with research groups hosted also at non-university institutions and runs numerous stimulating collaborations on Campus such as within the Collaborative Research Center CRC1690 (Disease Mechanisms and Functional Restoration of Sensory and Motor Systems, https://sfb1690.uni-goettingen.de) and the newly founded Else Kröner Fresenius Center for Optogenetic Therapies (EKFZ: https://ekfz.uni-goettingen.de).

Your tasks

• In-depth structural and functional characterization of optimized Channelrhodopsin variants for basic research in neuroscience and future optogenetic therapies
• Recombinant protein purification, Determination of protein stability (Prometheus NT. 48, NanoTemper Technologies), SDS PAGE, Blue Native PAGE
• Cryo-EM (Titan Krios G4, Thermo Fisher Scientific)
• High-throughput spinning disc confocal microscopy (CQ1, Yokogawa)
• Data analysis

Your qualifications

• Excellent and highly motivated applicant with a strong background in the structural and functional characterization of membrane transport proteins
• Proficiency in structural biology and preferably knowledge in bioinformatics and/or patch clamp measurements and/or data-driven protein design
• Experience with basic molecular biology techniques (PCR, cloning etc.)
• Preferably knowledge in the characterization of microbial rhodopsins
• Skills in data analysis with Python
• Excellent organizational, interpersonal and communication skills
• The ability to work in an interdisciplinary and international team of researchers is required

We offer

• Exciting work and collaboration in a multi-disciplinary team
• A highly innovative project
• The chance to contribute to work towards the development of future optogenetic therapies, in particular the optical cochlear implant

Our goal as University Medical Center Göttingen is professional equality for all genders. We strive to equalize the gender ratio in areas where there is underrepresentation. The University Medical Center Göttingen is particularly committed to the professional participation of severely disabled people and therefore welcomes applications from severely disabled people. In the case of equal suitability, applications from severely disabled persons will be given preferential consideration in accordance with the relevant regulations. We kindly ask you to indicate a disability/equal status in your letter of application in order to safeguard your interests.

Universitätsmedizin Göttingen

Institut für Auditorische Neurowissenschaften

Dr. Thomas Min-Ho Mager

Robert-Koch-Straße 40

37075 Göttingen

0551/39-20719

http://www.auditory-neuroscience.uni-goettingen.de/