Postdoc (m/w/d)

Philipps-Universität Marburg; Marburg; On-site; EUR 55,000 - 70,000; Full time

Benefits offered by this job

Equal Pay according to the Hesse Kolek

Public transport ticket in Hesse

Career development training

Collaborative, supportive research env

Professional development opportunities

Job summary

The University of Marburg's Department of Biology invites applications for a Research Assistant (Postdoc) to advance optical biosensors that measure GPCR conformational dynamics in living cells and to assess GPCR responses to ligands and mechanical signals. You will contribute to data analysis and structural modeling in a collaborative setting.

The position is a full-time, three-year contract under the TV-H E13 pay scale, with starting date as soon as possible.

Qualifications

• MSc or PhD in the life sciences; near completion of doctoral studies.
• Extensive experience in molecular biology for cloning fusion proteins.
• Extensive experience in pharmacological assays in living cells (≥96-well).
• Previous GPCR, G protein, GRK or arrestin related research questions.
• Experience in designing and validating new Biosensors in living cells.
• Very good English skills.

Responsibilities

• Design and cloning of optical biosensors to measure GPCR conformational dynamics.
• Validate optical biosensors in living cells.
• Apply biosensors to characterize GPCR responses to ligands and signals.
• Design and performance of pharmacological assays in microtiter plates (≥96-well).
• Analyze and visualize large pharmacological datasets.
• Structural modeling of GPCR-ligand interactions.

Skills

Biosensor design

GPCR assays

Pharmacology in living cells

Protein fusion design

Data analysis & visualization

GPCR-ligand modeling

Education

MSc or equivalent in life sciences

PhD near completion

Job description

The University of Marburg, founded in 1527, offers a variety of excellent programs of study for around 22,000 students and confronts the important topics of our time through excellent research across a broad spectrum of sciences.

The Department of Biology research group on “Developmental Genetics and Cell Biology of Animals”, Prof. Dr. Christian Helker, is currently accepting applications for a Research Assistant (Postdoc). The position is offered for a period of 3 years, if no former times of qualification must be considered. The starting date is as soon as possible. The position is fulltime with salary and benefits commensurate with a public service position in the state Hesse, Germany (TV-H E 13).

Entry date:

as soon as possible

Application deadline:

2026-11-22

Salary:

E 13 TV-H

Duration:

3 years

Volume of employment:

fulltime

• design and cloning of optical biosensors to measure conformational dynamics of G protein-coupled receptors (GPCRs)
• validation of optical biosensors in living cells
• application of optical biosensors to characterize GPCRs responses to ligand and mechanical signals
• design and performance of pharmacological, cell biological assays in microtiter plates (≥ 96-well)
• analysis and visualisation of large pharmacological datasets
• Structural modeling of GPCR-ligand interactions

The position will be filled by a temporary contract that is limited to the period which is necessary to gain further scientific expertise (such as the preparation for a subsequent qualification period). Within the entrusted tasks the opportunity for independent scientific work to obtain further personal qualification is given. The limitation complies with Section 2 (1) of the German Academic Fixed-Term Contract Act (WissZeitVG).

• MSc degree or equivalent and a Ph.D. in the life sciences or evidence of near completion of doctoral studies
• extensive experience in molecular biology techniques required for the cloning of new fusion proteins
• extensive experience in performing pharmacological assays in living cells in microtiter plate format (≥ 96-well)
• previous work on GPCR, G protein, GRK or arrestin related research questions
• experience in the design and validation of new biosensors used in living cells is desireable
• very good English skills

• equal Pay according to the Hesse Collective Agreement
• ticket for free use of public transport in the state Hesse, Germany
• career development training for junior scientists including postdoctoral researchers
• A collaborative, innovative, and supportive research environment
• Professional development opportunities, including training, coaching, and mentoring