Master Thesis for Multiplex digital PCR using High-Density Microwell Arrays (m/f/x)

Hahn-Schickard; Freiburg im Breisgau; Vor Ort; EUR 40.000 - 60.000; Vollzeit

Zusammenfassung

A research institute in microsystems technology is offering a Master Thesis focusing on Multiplex digital PCR using High-Density Microwell Arrays. The ideal candidate will study Biochemistry, Biotechnology, or a related field and have lab experience with pipetting and PCR. Responsibilities include assay development, comparing systems, and data analysis. The role promises flexible hours and a dynamic team in Freiburg, suitable for those eager to contribute to molecular diagnostics enhancements.

Leistungen

Flexible working hours

Insights into current digital PCR development

Close supervision and idea contribution

Young dynamic team

Attractive workplace in a modern research institute

Participation in health programmes

Subsidy for meals

Subsidies for public transport

Qualifikationen

• Required studies in a relevant STEM field.
• Must have lab experience with pipetting and PCR.
• Good command of English or German is necessary.

Aufgaben

• Implement a multiplex Mediator Probe dPCR assay on the LabDisk.
• Validate LabDisk performance against commercial dPCR systems.
• Analyze high-density multiplex data.

Kenntnisse

Lab experience (pipetting/PCR)

Interest in bioanalytics

Good English or German

Ausbildung

Studies in Biochemistry, Biotechnology, Molecular Biology, Medical Engineering or related STEM discipline

Jobbeschreibung

Overview

Welcome to Hahn-Schickard: The research center for innovative microsystems technology. With a team of over 300 employees, we transform ideas into cross-industry solutions - from conception to production at four locations in Baden-Württemberg. At our Freiburg site, the emphasis is on developing analytical solutions in microsystems technology, particularly for point-of-care diagnostics.

For the area of Microfluidic Platforms in Freiburg, we offer from 01.04.2026 or later a Master Thesis for Multiplex digital PCR using High-Density Microwell Arrays (m/f/x). Aim of the thesis:

Aim of the thesis

• Multiplexing in digital PCR is often limited by "partition-specific competition" in commercial devices (≈25,000 partitions), where co-encapsulated targets compete for reagents.
• The goal of the thesis is to demonstrate how a LabDisk, with its high-density array of 250,000 microwells, eliminates this competition to ensure robust quantification of liquid biopsy targets like KRAS.

Your Tasks

• Assay Development: Implement a multiplex Mediator Probe dPCR assay on the LabDisk.
• Comparison: Validate LabDisk performance against commercial dPCR systems.
• Data Analysis: Analyze high-density multiplex data.

Your profile

• Studies: Biochemistry, Biotechnology, Molecular Biology, Medical Engineering, or a related STEM discipline.
• Skills: Lab experience (pipetting/ PCR) and interest in bioanalytics.
• Work Style: Independent and structured.
• Language: Good English or German.

Our offer to you

• Flexible working hours
• Insights into current digital PCR development for molecular diagnostics
• Close supervision and the opportunity to contribute your own ideas
• A young and dynamic team
• An attractive workplace in a modern, excellently equipped research institute that is close to industry
• Participation in first-class health programmes such as Hansefit
• Subsidy for meals
• Subsidies for public transport

Your Application

Mr. Dr. Peter Jülg will be pleased to answer any question you may have.

[e-mail] / Tel.: [phone]

If you are interested, please send us your complete application documents (motivation letter/resume+CV/certificates/transcript of records), stating the reference number 26/3240/02 in a complete PDF document and naming the job portal here online via the application form.

The decision is made directly by the division.