Research Associate & Stem Cell Process Development & GMP Manufacturing

BioTalent Canada; Edmonton; On-site; CAD 80,000 - 112,000; Full time

Job summary

A leading research institution in Canada is seeking a Senior Research Associate to drive cell therapy process development in a pivotal role for advancing clinical treatments. Candidates must have a PhD in Islet Biology or Stem Cell Regenerative Medicine and substantial experience in stem cell research and manufacturing protocols. This role involves leading laboratory operations, ensuring quality compliance, and collaborating on clinical trials. A competitive annual salary range of $80,772 to $111,086 is offered to successful applicants.

Benefits

Comprehensive health benefits

Engaging research environment

Opportunities for professional development

Qualifications

• Minimum 5 years of postdoctoral experience plus 2 years as a research associate.
• Extensive background in stem cell biology and transplantation.
• Expert knowledge in pancreatic cell differentiation.

Responsibilities

• Lead GMP process development and optimize manufacturing protocols.
• Execute quality testing and regulatory documentation management.
• Publish research and present findings at scientific conferences.

Skills

Pluripotent stem cell biology

Somatic cell reprogramming

Pancreatic cell differentiation

Gene editing (CRISPR/Cas9)

Flow cytometry

Surgical skills for islet transplantation

Advanced gene sequencing

Education

PhD in Islet Biology or Stem Cell Regenerative Medicine

Tools

PCR/Gene array

Immunohistochemistry

ELISA assays

Job description

Overview

• Job Identification: 3495
• Posting Date: 02/04/2026, 08:42 PM
• Apply Before: 3/7/2026
• Job Schedule: Full Time
• Locations: Edmonton, AB, Canada (On-site)
• Category Type: Laboratory and Research
• Position Type: Trust Research Academic Staff (TRAS)
• College/Administrative Portfolio: College of Health Sciences
• Annual Salary Range: $80,772 to $111,086

About the Team

The https://www.ualberta.ca/en/medicine/index.html is one of the world’s top academic health science centres. With 21 departments, multiple research institutes and centres, and a focus on excellence in education, research, and clinical care, the faculty trains outstanding medical and dental professionals and drives global health innovation in collaboration with partners across sectors.

Description

This position has an initial appointment of 12 months.

Location – This role is in-person at North Campus Edmonton.

The Shapiro Stem Cell Diabetes Lab, led by Principal Investigator Dr. James Shapiro, is seeking a highly qualified Senior Research Associate to drive Cell Therapy Process Development and Manufacturing of autologous islets derived from human pluripotent stem cells. This role is pivotal in establishing a core stem cell facility and advancing translational research into clinical cell therapies, with a focus on pancreatic cell development and differentiation.

We are seeking a Researcher who can:

• Lead bioengineering research on human pluripotent stem cells, optimizing processes for large-scale manufacturing of clinical-grade stem cell and islet products.
• Develop and implement Standard Operating Procedures (SOPs) for pre-GMP and GMP-compliant cell manufacturing, ensuring adherence to regulatory standards.
• Independently plan, execute, and analyze complex experiments to produce high-quality, safe, and functional stem cell-derived islet cell products.
• Collaborate with the Clinical Islet Transplant Program (CITP) to support translational research and clinical trials for novel patient treatments.

Why Join Us?

This role offers the opportunity to contribute to cutting-edge research in stem cell therapy and diabetes treatment, working alongside a world-renowned team at the Alberta Diabetes Institute. You’ll play a key role in translating scientific discoveries into life-changing clinical applications while adhering to the highest standards of quality and safety.

Responsibilities

• GMP Process Development & Technology Transfer: Lead high-level research design, optimize manufacturing protocols, manage technology transfer and drive protocol implementation.
• Advanced Research & Laboratory Operations: Manage laboratory facilities, execute cutting-edge experiments, drive automation innovation, data analysis.
• Quality Control & Regulatory Compliance: Execute quality testing, manage regulatory documentation, ensure data integrity, SOP management.
• Scholarly Dissemination and Communication: Publish research findings, present scientific findings at lab meetings, national and international scientific conferences, collaborate on reporting with the PI and collaborators.
• Financial and Grant Management to support the CITP Operations Director: Manage budgets, secure funding, manage space and equipment grants.
• Personnel Leadership and Supervision: Support the CITP Operations director with supervision of lab staff by providing daily oversight of research personnel.
• Supports the Operations Director with recruitment activities to hire postdoctoral fellows, technicians and graduate students, provide training and mentorship to research personnel, public relations activities along side the PI to promote the labs work.

Qualifications

• PhD in Islet Biology, Stem Cell Regenerative Medicine, or a related discipline.
• Required Experience: A minimum of 5 years of postdoctoral experience plus 2 years of previous research associate experience.
• Research Focus: Extensive background in pluripotent stem cell biology, somatic cell reprogramming, pancreatic development, islet biology, physiology, and/or transplantation with a proven high-quality publication record.
• Stem Cell Expertise: Extensive hands-on experience with Human ESC/iPSC culture and somatic cell reprogramming.
• Differentiation: Expert knowledge in pancreatic cell differentiation and the generation of islet cells in 2D and 3D culture systems (planar, suspension bags, and 3D suspension bioreactor-based cell culture).
• Manufacturing: Knowledge of gene-edited cell manufacturing and cell processing for clinical grades.
• Core Assays: Proficiency in immunohistochemistry, advanced molecular microscopy, real-time gene expression (PCR/Gene array), and ELISA assays.
• Advanced Genomics: Skills in single-cell RNA sequencing (sc-RNA seq) data generation/analysis, spatial transcriptomics, and karyotyping.
• Gene Editing: Experience with CRISPR/Cas9 technology (vector production and gene editing).
• Surgical Skills: Hands-on experience with animal surgeries, specifically islet transplantation.
• Procedures: Proficiency in dosing, injections, IPGTTs (Intraperitoneal Glucose Tolerance Tests), as well as blood and tissue collection.
• Flow Cytometry: Expert knowledge and skills in multi-parameter flow cytometry.
• Research Design: High-level skills in experimental design, data analysis, and troubleshooting.
• Regulatory Knowledge: Demonstrated knowledge of GLP (Good Laboratory Practice) and GMP (Good Manufacturing Practice) procedures, including reviewing and approving GMP SOPs.
• Communication: Strong verbal and written science communication skills for manuscript and abstract writing, presentations, and drafting/submitting research funding applications (including CFI).
• Management: Experience in designing and developing core facilities, along with supervisory and project management duties.

Application Instructions

Click “Apply Now” to submit your curriculum vitae and list of publications.

This position offers comprehensive benefits with an annual salary range of $80,772 to $111,086.

The terms and conditions of this appointment are governed by the Collective Agreement between the Board of Governors of the University of Alberta and the Association of the Academic Staff of the University of Alberta.

About Us

The University of Alberta acknowledges that we are located on Treaty 6 territory, and respects the histories, languages and cultures of First Nations, Métis, Inuit and all First Peoples of Canada, whose presence continues to enrich our vibrant community.

The University of Alberta is a community of knowledge seekers, change makers and world shapers who lead with purpose each and every day. We are home to over 14,000 faculty and staff, more than 40,000 students and a growing community of 300,000 alumni worldwide.

Your work will have a meaningful influence on a fascinating cross-section of people – from our students and community members, to our renowned researchers and innovators, making discoveries and generating solutions that make the world healthier, safer, stronger and more just.

All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority. If suitable Canadian citizens or permanent residents cannot be found, other individuals will be considered.

At the University of Alberta, we are committed to creating an inclusive and accessible hiring process for all candidates. If you require accommodations to participate in the interview process, please let us know at the time of booking your interview and we will make every effort to accommodate your needs.

We thank all applicants for their interest; however, only those individuals selected for an interview will be contacted.

All University employees have a responsibility to foster a workplace that prioritizes safety in all its forms – physical, cultural, and psychological. This is achieved by promoting a safe environment, adhering to all safety laws, policies and procedures, completing all required safety training, identifying hazards and implementing controls, reporting incidents, and contributing to a culture of belonging and respect, while endeavoring to ensure that all colleagues feel valued and safe to express their thoughts, perspectives and concerns.

The University of Alberta is committed to creating a university community where everyone feels valued, barriers to success are removed, and thriving connections are fostered. We welcome applications from all qualified persons. We encourage women, First Nations, Métis and Inuit persons, members of visible minority groups, persons with disabilities, persons of any sexual orientation or gender identity and expression, and all those who may contribute to the further diversification of ideas and the University to apply.

To apply, visit https://apptrkr.com/6905147