Process Development Chemist - Scale-Up for APIs (Hybrid)

Placements24; Randburg; Hybrid; ZAR 900,000 - 1,500,000; Full time

Benefits offered by this job

Hybrid work model

Competitive salary

Healthcare and retirement benefits

Job summary

Placements24 in Randburg, South Africa, is seeking an experienced Senior Research Chemist specialized in Process Development to lead scalable API and intermediate synthesis, driving robust, cost-effective routes from lab to pilot scale.

The role emphasizes process safety, analytical method development (HPLC, GC, NMR, Karl Fischer), and collaboration with engineering and manufacturing to ensure successful tech transfer, regulatory support, and ongoing professional development.

Qualifications

• M.Sc. or Ph.D. in Organic Chemistry, Process Chemistry, or a related field.
• Minimum of 5 years of experience in process development within the pharmaceutical or fine chemical industry.
• Proven expertise in synthetic route design, optimization, and scale-up.
• Strong understanding of chemical engineering principles and safety protocols.
• Experience with analytical techniques such as HPLC, GC, NMR, and Karl Fischer titration.

Responsibilities

• Design, optimize, and scale-up synthesis routes for APIs and intermediates.
• Conduct process hazard analyses and implement safe operating procedures.
• Develop robust analytical methods to monitor reaction progress and product quality.
• Troubleshoot and resolve process-related issues encountered during scale-up and manufacturing.
• Collaborate with engineering and manufacturing teams to ensure successful technology transfer.
• Author comprehensive process development reports and contribute to regulatory filings.

Skills

Process development

Scale-up

Hazard analysis

Team collaboration

Education

MSc or PhD in Organic/Process Chemistry

Tools

HPLC

GC

NMR

Karl Fischer titration

Job description

Placements24 in Randburg, South Africa, is seeking an experienced Senior Research Chemist specialized in Process Development to lead scalable API and intermediate synthesis, driving robust, cost-effective routes from lab to pilot scale.

The role emphasizes process safety, analytical method development (HPLC, GC, NMR, Karl Fischer), and collaboration with engineering and manufacturing to ensure successful tech transfer, regulatory support, and ongoing professional development.