Senior Pharma Process Chemist - Scale-Up (Hybrid)

Placements24; Klerksdorp; Hybrid; ZAR 1,100,000 - 1,500,000; Full time

Benefits offered by this job

Health insurance

Hybrid work model

Professional development

Laboratory access

Job summary

Placements24 in Klerksdorp, South Africa, is seeking an experienced Senior Pharmaceutical Process Chemist to join the Process Development team. You will scale up and optimize synthesis routes for APIs, applying organic chemistry and process engineering to ensure safe, cost-effective production.

The role involves transitioning discoveries to robust manufacturing processes in a hybrid work setting. The ideal candidate has 5+ years in pharmaceutical process development or manufacturing, strong

Qualifications

• Master's or PhD in Organic Chemistry, Process Chemistry, or a related field.
• Minimum of 5 years of experience in pharmaceutical process development or chemical manufacturing.
• Strong understanding of organic synthesis, reaction mechanisms, and process safety.
• Experience with scale-up challenges, process optimization, and route scouting.
• Proficiency with analytical techniques for chemical characterization.
• Familiarity with cGMP requirements for pharmaceutical manufacturing.

Responsibilities

• Develop and optimize synthetic routes for APIs, focusing on yield, purity, safety, and cost-effectiveness.
• Scale-up chemical processes from laboratory bench to pilot plant and manufacturing scale.
• Conduct process hazard analyses and implement appropriate safety measures for chemical operations.
• Troubleshoot and resolve technical issues encountered during process development and manufacturing.
• Characterize intermediates and final APIs using various analytical techniques (NMR, MS, HPLC, GC).
• Write detailed process development reports, batch records, and technology transfer documentation.

Skills

Organic synthesis

Process chemistry

Scale-up experience

Analytical techniques

Problem solving

Education

Master's degree in Organic Chemistry

PhD in Organic/Process Chemistry

Tools

NMR

MS

HPLC

GC

Job description

Placements24 in Klerksdorp, South Africa, is seeking an experienced Senior Pharmaceutical Process Chemist to join the Process Development team. You will scale up and optimize synthesis routes for APIs, applying organic chemistry and process engineering to ensure safe, cost-effective production.

The role involves transitioning discoveries to robust manufacturing processes in a hybrid work setting. The ideal candidate has 5+ years in pharmaceutical process development or manufacturing, strong