Upstream Process Development Scientist for Biologics

Johnson & Johnson Innovative Medicine; North Carolina; On-site; USD 90,000 - 140,000; Full time

Job summary

Johnson & Johnson Innovative Medicine in Spring House, PA seeks a Scientist, Upstream Process Development to advance scalable cell culture processes for biotherapeutics. Lead bioreactor-based development, optimize media, and drive data-driven decisions across cross-functional teams.

The role emphasizes DOE, Ambr 250 operation, and collaboration with analytical, automation, and formulation groups to deliver quality process improvements and regulatory-ready documentation.

Qualifications

• BS or MS in a related field with 2–4+ years of relevant experience.
• Experience in mammalian cell culture process development for biologics, cell and gene therapy, RNA therapeutics, or related viral vector modalities.
• Hands-on experience with bioreactor operation, media optimization, process monitoring, and scale-up support.
• Strong data analysis, experimental design, and technical documentation skills.

Responsibilities

• Design and execute upstream process development studies for lentiviral in vivo therapeutic products under scientific guidance.
• Perform cell culture experiments using shake flasks, bench-scale bioreactors, and automated high-throughput systems.
• Support development of scalable fed-batch and perfusion processes to improve productivity, quality, and manufacturability.
• Utilize Ambr 250 bioreactor systems for process development, media optimization, and scale-down model studies.
• Apply statistical experimental design, data analytics, and visualization tools to support process understanding and decision-making.
• Build working knowledge of Process Analytical Technology, Raman spectroscopy, online monitoring, and digital bioprocessing tools.
• Analyze and interpret process data using JMP, MiniTab, Python, Spotfire, or similar platforms.
• Support evaluation of novel upstream technologies that improve process robustness and development efficiency.
• Collaborate with downstream, analytical, automation, modeling, and formulation teams to align study design and deliverables.
• Author technical reports, development summaries, protocols, and regulatory-supporting documentation.

Skills

Mammalian cell culture

Statistical design

Cross-functional teamwork

Data analysis

Education

BS/MS in Chemical Engineering or Biochemical/ Biological Sciences

Tools

Ambr 250

JMP

MiniTab

Python

Spotfire

Job description

Johnson & Johnson Innovative Medicine in Spring House, PA seeks a Scientist, Upstream Process Development to advance scalable cell culture processes for biotherapeutics. Lead bioreactor-based development, optimize media, and drive data-driven decisions across cross-functional teams.

The role emphasizes DOE, Ambr 250 operation, and collaboration with analytical, automation, and formulation groups to deliver quality process improvements and regulatory-ready documentation.