Associate Scientist, Downstream Processing

Johnson Johnson; Malvern (Chester County); On-site; USD 90,000 - 120,000; Full time

Job summary

Johnson & Johnson in Malvern, PA, seeks an Associate Scientist in Downstream Processing to support biologics purification process development within the Protein Therapeutics API Development group. You will assist in bench-scale experiments, focusing on chromatography and filtration, to advance early-phase programs for biotherapeutics.

The role requires collaboration with upstream, analytical, formulation, and manufacturing teams, strong documentation, and adherence to cGxP and EHSS policies.

Qualifications

• B.S. or M.S. in a related discipline with relevant experience.
• Familiarity with protein purification, bioprocessing, or related methods.
• Basic understanding of experimental design and analysis.
• Self-motivated, eager to learn, and well organized.
• Strong written and verbal communication skills.
• Proficiency with MS Office (Excel, Word, PowerPoint).

Responsibilities

• Define work packages and purification development strategies for NME candidates.
• Execute chromatography and filtration experiments focusing on product quality.
• Assist in process characterization, scale-up, and technology transfer.
• Collaborate cross-functionally with upstream, analytical, formulation, and manufacturing teams.
• Author and review technical or regulatory documents.
• Maintain accurate records and comply with EHSS policies.
• Capture data accurately and maintain compliant records.

Skills

Protein purification

Bioprocessing

Experimental design

MS Office

Education

B.S. in Chemical Engineering/Biochemistry/Biotechnology

M.S. in Chemical Engineering/Biochemistry/Biotechnology

Tools

AKTA FPLC

JMP

Minitab

Job description

Job Function

Discovery & Pre-Clinical/Clinical Development

Job Sub Function

Biotherapeutics R&D

Job Category

Scientific/Technology

All Job Posting Locations

Malvern, Pennsylvania, United States of America

Job Description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

We are searching for the best talent for our Associate Scientist, Downstream Processing position, to be located in Malvern, PA.

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

Purpose: The Associate Scientist, Downstream Processing supports biologics purification process development within the Protein Therapeutics API Development (Downstream Purification) organization. This role will support purification process development for protein therapeutics. The Associate Scientist will assist in design, execution, and documentation of bench-scale laboratory experiments for protein purification operations including chromatography (affinity, ion-exchange, hydrophobic interaction) and filtration (UFDF, TFF, depth filtration). This person will contribute individually and as part of a team to meet project timelines and objectives with an emphasis on early-phase process development for preclinical therapeutics. The Associate Scientist will also maintain compliance with data documentation, safety, and other company policies and procedures.

You will be responsible for

• Defining work packages and streamlining purification development strategies for new molecular entity (NME) candidates to support early phase clinical manufacturing of biotherapeutics (monoclonal antibodies, bi/multi-specific antibodies, bioconjugates, and other)
• Executing chromatography and filtration experiments with a focus on product quality attributes, product recovery, and manufacturing facility fit constraints
• Assisting in process characterization, process scale-up, and technology transfer of downstream unit operations
• Working cross functionally with upstream (cell culture), analytical development, formulation sciences, and manufacturing organizations to meet overall program deliverables and timelines
• Authoring and reviewing technical or regulatory documents
• Keeping accurate records, following instructions, and complying with company and EHSS policies.
• Capturing data accurately and in a timely manner, maintain detailed records in compliance with applicable cGLP, safety, and environmental requirements.

Qualifications / Requirements

Required

• B.S degree in Chemical Engineering, Biochemistry, Biotechnology, or related discipline with 0 - 5 years of relevant experience OR M.S degree in Chemical Engineering, Biochemistry, Biotechnology, or related discipline with 0 - 3 years of relevant experience.
• Familiarity with protein purification, bioprocessing, or related scientific methodology
• Basic understanding of experimental design, performance, and analysis
• Self-motivated and eager to learn
• Strong written and verbal communication skills
• Highly organized and capable of working in both a team environment and individually with limited supervision
• Proficiency in MS Office (Excel, Word, PowerPoint)

Preferred

• Solid understanding of statistical experimental design and analysis (DoE methodology)
• Hands-on experience working with Akta fast protein liquid chromatography (FPLC) systems
• Hands-on experience in protein bioprocessing techniques such as chromatography, filtration (depth, tangential flow, UFDF), and/or analytical methods (SDS-PAGE, UV/Vis, etc.)
• Experience working with statistical design software such as JMP, minitab, or related programs

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected