Upstream Bioprocess Scientist for Biologics & Scale-Up

Johnson & Johnson Innovative Medicine; Spring House (PA); On-site; USD 90,000 - 120,000; Full time

Job summary

Johnson & Johnson is seeking a Scientist, Upstream Process Development in Spring House, PA to advance scalable cell culture processes for in vivo programs.

The role emphasizes bioreactor execution, media optimization, and data-driven process understanding for next-generation biologics and gene therapies. Collaboration across teams and rigorous documentation are essential for regulatory-ready outcomes.

Qualifications

• BS/ MS in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field.
• Experience in mammalian cell culture process development for biologics or gene therapy.
• Hands-on bioreactor operation, media optimization, and scale-up support.

Responsibilities

• Design and execute upstream process development studies for lentiviral in vivo therapeutic products.
• Perform cell culture experiments using shake flasks, bench-scale bioreactors, and automated high-throughput systems.
• Support development of scalable fed-batch and perfusion processes to improve productivity, quality, and manufacturability.
• Utilize Ambr 250 bioreactor systems for process development, media optimization, and scale-down model studies.
• Apply statistical experimental design, data analytics, and visualization tools to support process understanding and decision-making.
• Build working knowledge of Process Analytical Technology, Raman spectroscopy, online monitoring, and digital bioprocessing tools.
• Analyze and interpret process data using JMP, MiniTab, Python, Spotfire, or similar platforms.
• Support evaluation of novel upstream technologies that improve process robustness and development efficiency.
• Collaborate with downstream, analytical, automation, modeling, and formulation teams to align study design and deliverables.
• Author technical reports, development summaries, protocols, and regulatory-supporting documentation.

Skills

Mammalian cell culture

Bioreactor operation

Data analysis

Cross-functional collaboration

Education

BS or MS in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field

Tools

Ambr 250

JMP

Minitab

Python

Spotfire

Job description

Johnson & Johnson is seeking a Scientist, Upstream Process Development in Spring House, PA to advance scalable cell culture processes for in vivo programs.

The role emphasizes bioreactor execution, media optimization, and data-driven process understanding for next-generation biologics and gene therapies. Collaboration across teams and rigorous documentation are essential for regulatory-ready outcomes.