Single-Cell Genomics Assay Productization Scientist I

10x Genomics

Pleasanton (CA)

On-site

USD 90,000 - 130,000

Full time

16 hours ago

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Job summary

10x Genomics seeks a Scientist I to join the Assay Productization team, supporting development and launch of new Single Cell Genomic products in a fast-paced environment. You will work with R&D, Production, QC, and Manufacturing to validate novel reagents and drive product readiness.

Your role involves independent experiments, data interpretation, and clear communication of results to stakeholders, with a focus on NGS workflows and reagent development for cross-functional success.

Qualifications

BS in molecular biology, biochemistry, genetics, analytical chemistry, or a related field with 5+ years of relevant experience.
MS with 3+ years; or PhD with 1+ year.
Hands-on experience with NGS library generation, data evaluation, and next-generation sequencing workflows.
Prior work in a process or product development role, including technology transfer to manufacturing and/or QC groups.
Solid understanding of molecular biology fundamentals and reagent or assay development.
Proficiency with analytical techniques including qPCR, HPLC, Enzymatic Assays, and instrumentation such as Bioanalyzers or Fragment Analyzers.
Ability to independently design, execute, analyze, and interpret multi-step experiments with diligent attention to planning, organization, and record keeping.
Experience troubleshooting molecular biology-based assays and identifying root cause of failures.
Familiarity with manufacturing documentation systems and quality processes (e.g., batch records, ECOs).
Strong collaboration and communication skills, with the ability to work effectively across scientific and operational teams.
Self-motivated with the ability to manage and prioritize work independently in a fast-paced environment.

Responsibilities

Independently design experiments, including NGS library preparation from single cells, tissues, or isolated DNA/RNA using 10x instruments and consumables.
Draft, maintain, and update manufacturing readiness documentation, including production batch records, without assistance.
Optimize and refine quality control (QC) methods and assays to assess reagent quality through a variety of analytical and functional tests.
Own AP deliverables end-to-end for low complexity projects, and contribute to complex projects under guidance from an AP lead.
Perform troubleshooting of failed experiments and reagent issues as they arise, identifying root cause and determining best course of action.
Support reagent guard banding and stability studies.
Update parts and shelf-life documentation, including Part Specifications and Receiving Inspection Records (PS/RIR), via Engineering Change Orders (ECOs).
Facilitate handoffs from R&D to Operations by training QC and Production staff on new workflows and methods.
Present experimental data and results clearly to internal stakeholders, with well-reasoned interpretation and analysis.
Communicate identified risks appropriately and proactively, and collaborate cross-functionally to resolve issues.