Senior Translational PBPK Scientist

Genentech; South San Francisco (CA); On-site; USD 124,000 - 231,000; Full time

Job summary

Genentech seeks a PhD-level Senior Scientist in DMPK to advance PBPK modeling for small molecules. You will strategize, execute, and report simulations, and present findings to cross-functional teams and senior management.

The role emphasizes leadership in modeling across discovery and development projects, coordinating non-clinical studies and DMPK strategy, with relocation possible within the domestic footprint.

Qualifications

• PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or related field with 2+ years of industry or post‑doc experience.
• Expertise in PBPK modeling and quantitative pharmacology; hands-on with PBPK platforms such as Simcyp, GastroPlus, or PK-Sim.
• Strong communication and organizational skills with track record of thriving in cross-functional teams.

Responsibilities

• Strategize, plan, and execute PBPK modeling and simulations independently.
• Present work at cross-functional teams, department meetings, and regulatory interactions.
• Lead DMPK strategy and report non-clinical studies; represent DMPK at discovery and development teams.

Skills

PBPK modeling

Quantitative pharmacology

cross-functional teamwork

Education

PhD in Pharmacokinetics/Drug Metabolism/Pharmaceutical Sciences

Tools

Simcyp

GastroPlus

PK-Sim

Phoenix

R

NONMEM

SimBiology

Python

Job description

Genentech seeks a PhD-level Senior Scientist in DMPK to advance PBPK modeling for small molecules. You will strategize, execute, and report simulations, and present findings to cross-functional teams and senior management.

The role emphasizes leadership in modeling across discovery and development projects, coordinating non-clinical studies and DMPK strategy, with relocation possible within the domestic footprint.