Sr. Scientist - Translational PBPK Modeling

Genentech; South San Francisco (CA); On-site; USD 124,000 - 231,000; Full time

Job summary

Genentech seeks a PhD-level Senior Scientist in DMPK to advance PBPK modeling for small molecules. You will strategize, execute, and report simulations, and present findings to cross-functional teams and senior management.

The role emphasizes leadership in modeling across discovery and development projects, coordinating non-clinical studies and DMPK strategy, with relocation possible within the domestic footprint.

Qualifications

• PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or related field with 2+ years of industry or post‑doc experience.
• Expertise in PBPK modeling and quantitative pharmacology; hands-on with PBPK platforms such as Simcyp, GastroPlus, or PK-Sim.
• Strong communication and organizational skills with track record of thriving in cross-functional teams.

Responsibilities

• Strategize, plan, and execute PBPK modeling and simulations independently.
• Present work at cross-functional teams, department meetings, and regulatory interactions.
• Lead DMPK strategy and report non-clinical studies; represent DMPK at discovery and development teams.

Skills

PBPK modeling

Quantitative pharmacology

cross-functional teamwork

Education

PhD in Pharmacokinetics/Drug Metabolism/Pharmaceutical Sciences

Tools

Simcyp

GastroPlus

PK-Sim

Phoenix

R

NONMEM

SimBiology

Python

Job description

The Position

The Drug Metabolism and Pharmacokinetics (DMPK) group is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state-of-the-art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

Opportunity

The DMPK department at Genentech is seeking a Ph.D. level Senior Scientist who is highly motivated to apply cutting edge translational modeling approaches to support the advancement of small molecule drug discovery and development projects. Physiologically-based Pharmacokinetic (PBPK) modeling will be a key focus of this position. Key technical responsibilities are to strategize, plan, execute, and report PBPK modeling and simulations independently, as well as to present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences. Other responsibilities may also include representing DMPK at multi-functional discovery and development project teams and leading the DMPK strategy, including designing, executing and reporting non-clinical studies.

Who You Are

• You hold a PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or a related scientific field, paired with 2 years relevant industry or post-doctoral experience in drug discovery/development.
• You bring expertise in PBPK modeling and quantitative pharmacology, with hands-on experience using platforms such as Simcyp, GastroPlus, or PK-Sim.
• You demonstrate strong communication and organizational skills, with a track record of thriving within cross-functional team environments.

Preferred

• Experience with additional modeling and simulation tools, such as Phoenix, R, NONMEM, SimBiology, Python.
• Prior pharmaceutical industry experience as a DMPK project leader.
• Experience supporting diverse modalities (small/large molecules, peptides, etc.) in drug development or modeling.

Together, we’ll advance along the whole patient journey with the aspiration to prevent, stop and cure diseases.

This position does offer domestic relocation.

The expected salary range for this position based on the primary location of San Francisco, CA is 124,300.00 - 230,900.00 USD. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.