Senior Scientist, Translational PK-PD (Biologics)

F. Hoffmann-La Roche AG; South San Francisco (CA); On-site; USD 121,000 - 224,000; Full time

Job summary

Genentech is seeking a Senior Scientist to support translational PKPD efforts, guiding preclinical design and data interpretation for biologics in development. You will lead in vitro and in vivo ADME/PKPD studies, compile summaries, and present findings to teams.

The role requires a PhD/MD/PharmD plus 1–2 years translational experience, with strong analytical skills and GLP familiarity. Collaboration across departments and potential publications are key aspects.

Qualifications

• Ph.D., M.D., or PharmD in pharmacology, pharmaceutical science, biology, or related field required
• 1-2 years industry PKPD/translational experience preferred
• Strong GLP and laboratory safety familiarity; able to work independently or with supervision

Responsibilities

• Design, conduct, analyze, and interpret in vitro/in vivo ADME and PKPD studies in animals to predict human behavior
• Prepare summary tables/reports for non-clinical studies and regulatory documents (INDs/BLAs) under supervision
• Present data at project teams and department meetings; contribute to publications in peer-reviewed journals
• Collaborate with Clinical Pharmacology, Bioanalytical Sciences, Regulatory Affairs, and other functions to advance development programs
• Maintain an active PKPD laboratory program supporting research and pipeline projects

Skills

PKPD knowledge

Critical thinking

Data analysis

Scientific communication

Regulatory awareness

Education

Ph.D./M.D./PharmD or equivalent

Postdoctoral experience (preferred)

Tools

WinNonlin

NONMEM

ADAPT II

Matlab

SimBiology

R

Job description

Genentech is seeking a Senior Scientist to support translational PKPD efforts, guiding preclinical design and data interpretation for biologics in development. You will lead in vitro and in vivo ADME/PKPD studies, compile summaries, and present findings to teams.

The role requires a PhD/MD/PharmD plus 1–2 years translational experience, with strong analytical skills and GLP familiarity. Collaboration across departments and potential publications are key aspects.