Senior Scientist: Targeted LNP Formulation

Basecamp Research; Cambridge (MA); On-site; USD 110,000 - 165,000; Full time

Benefits offered by this job

Healthcare

Equity

Carrot Fertility IVF stipend

Competitive salary

Job summary

Basecamp Research is seeking a Scientist/Senior Scientist, tLNP Formulation and Delivery, to join the Boston, MA team. You will own end-to-end design, formulation, bioconjugation, and physicochemical characterization of novel tLNPs and partner with cell biology to validate targeting and uptake in vivo.

You will work closely with AI-enabled ligand design and cross-functional teams to advance extrahepatic tissue tropism for next-generation gene therapies, with on-site work at our Boston facility.

Qualifications

• PhD in biomedical engineering, chemical engineering, chemistry, pharmaceutical sciences or related field.
• 1–2 years of relevant experience for Scientist or 3+ years for Senior Scientist; MSc with equivalent hands-on experience considered.
• Hands-on drug delivery foundations and entrepreneurial mindset required.

Responsibilities

• Develop targeted LNP technology to enable extrahepatic tissue tropism.
• Design and execute tLNP formulations with nucleic acid payloads.
• Direct third-party CROs to synthesize lipids of interest.
• Perform surface bioconjugation to attach targeting moieties to LNP surfaces.
• Conduct LNP analytics (DLS, encapsulation, zeta potential, etc.).
• Characterize LNP formulations for quality and optimization.
• Develop in vitro assays to evaluate binding, uptake, endosomal escape, and cargo translation.
• Design in vivo biodistribution and PK studies with the innovation team.
• Maintain ELN records and generate technical reports and patent disclosures.
• Collaborate with cell biology, innovation, and AI teams to inform iterative design.

Skills

LNP assembly

Bioconjugation

Tropism engineering

LNP analytics

In vivo studies

Documentation

Cross-functional collaboration

Education

PhD in biomedical/chemical engineering or related field

MSc with hands-on lab experience

Tools

NanoAssemblr

T-mixing

Ethanol injection

JMP (DoE software)

Job description

Basecamp Research is seeking a Scientist/Senior Scientist, tLNP Formulation and Delivery, to join the Boston, MA team. You will own end-to-end design, formulation, bioconjugation, and physicochemical characterization of novel tLNPs and partner with cell biology to validate targeting and uptake in vivo.

You will work closely with AI-enabled ligand design and cross-functional teams to advance extrahepatic tissue tropism for next-generation gene therapies, with on-site work at our Boston facility.