Senior Oligonucleotide Conjugation Scientist

Biopharma Careers; Cambridge (MA); On-site; USD 121,000 - 202,000; Full time

Benefits offered by this job

Health insurance

Retirement benefits

Paid holidays

Vacation

Parental leave

Caregiver leave

Job summary

GSK in Cambridge, MA is seeking a PhD-level chemist to establish pre-clinical capabilities in oligonucleotide conjugation, spanning ASOs, siRNA, SSO, and RNA editors. You will develop multistep syntheses, SOPs, and cross-team collaboration to advance ASO-related chemistry.

The role emphasizes hands-on synthesis, method development, and leadership in small molecule and lipid conjugate projects within a dynamic team. On-site, full-time position with strong focus on quality and reproducibility.

Qualifications

• PhD with 3+ years’ experience in chemistry, oligonucleotide synthesis, or chemical biology or related fields.

Responsibilities

• Establish pre-clinical oligonucleotide conjugation capabilities of ASOs, siRNA, SSO, and RNA editors with small molecules, lipids, linkers, and other conjugates with multistep synthesis from the milligram to gram scale.

Skills

Analytical Chemistry

Data Analysis

Design Thinking

Drug Design

Drug Discovery Process

Medicinal Chemistry

Synthetic Organic Chemistry

Education

PhD in Chemistry or related field

Tools

HPLC purification

LC/MS analytics

ÄKTA Avant / Pure purification systems

Job description

GSK in Cambridge, MA is seeking a PhD-level chemist to establish pre-clinical capabilities in oligonucleotide conjugation, spanning ASOs, siRNA, SSO, and RNA editors. You will develop multistep syntheses, SOPs, and cross-team collaboration to advance ASO-related chemistry.

The role emphasizes hands-on synthesis, method development, and leadership in small molecule and lipid conjugate projects within a dynamic team. On-site, full-time position with strong focus on quality and reproducibility.